Description

R(+)-Bay K 8644 is a high-purity, enantiomerically pure calcium channel activator widely used as a critical research tool in pharmacological studies. This compound, identified by CAS No. 98791-67-4, is valued for its stereospecific activity as an L-type calcium channel agonist, making it essential for investigating cardiovascular and neurological pathways. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and contract research organizations (CROs) focused on ion channel modulation and drug discovery.

Application

• Pharmacological Research: A key tool for studying L-type voltage-gated calcium channels (VGCCs) in excitable tissues.
• Cardiovascular Studies: Used to investigate positive inotropic effects, vascular smooth muscle contraction, and cardiac contractility mechanisms.
• Neuroscience Research: Employed in models to understand neurotransmitter release, neuronal excitability, and synaptic plasticity.
• Drug Discovery Screening: Serves as a reference agonist in high-throughput screening (HTS) assays for identifying novel calcium channel modulators.
• Biochemical Assays: Used in vitro to calibrate and validate functional assays measuring intracellular calcium flux.
• Academic & Institutional Research: Fundamental reagent for graduate and post-doctoral studies in molecular pharmacology and physiology.

Basic Information

Product Name	R(+)-Bay K 8644
CAS No.	98791-67-4
Molecular Formula	C22H24N2O6
Molecular Weight	412.44 g/mol
Synonyms	(R)-Bay K8644; (R)-(+)-Bay K 8644; Methyl 1,4-dihydro-2,6-dimethyl-3-nitro-4-(2-trifluoromethylphenyl)-pyridine-5-carboxylate; (R)-1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylic acid methyl ester; (R)-(+)-1,4-Dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-3-pyridinecarboxylic acid methyl ester; Bay K 8644 (R)-(+)-enantiomer; L-type calcium channel agonist (R)-enantiomer
EINECS	Contact for details

Quality Control

Our R(+)-Bay K 8644 is manufactured under strict quality systems to ensure batch-to-batch consistency and high enantiomeric purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for chemical purity and chiral purity and spectroscopic identification (IR, NMR). Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided to support your research integrity and documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, consider desiccant use.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% (R-enantiomer)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.