Description

S(-)-Bay K 8644 CAS NO 98625-26-4 is the enantiomerically pure, biologically active form of the well-known L-type calcium channel agonist. This high-purity chiral compound is essential for advanced pharmacological research, providing a critical tool for studying calcium channel function and modulation with high specificity. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and contract research organizations (CROs) focused on cardiovascular and neurological drug discovery.

Application

• Pharmacological Research: A key tool for studying the function and modulation of L-type voltage-gated calcium channels (VGCCs) in cellular and tissue models.
• Cardiovascular Studies: Used to investigate calcium influx in cardiac muscle cells, aiding in research on heart contractility, arrhythmias, and related therapeutic pathways.
• Neuroscience Research: Applied in studies of neurotransmitter release, neuronal excitability, and synaptic plasticity where L-type calcium channels play a regulatory role.
• Drug Discovery & Development: Serves as a reference standard and a pharmacological probe in high-throughput screening (HTS) and lead optimization for novel calcium channel modulators.
• Biochemical Assays: Employed in in vitro assays to characterize the potency and selectivity of new chemical entities targeting calcium channels.
• Academic & Institutional Research: A fundamental reagent for basic science research in university and government laboratories exploring cellular signaling mechanisms.

Basic Information

Product Name	S(-)-Bay K 8644
CAS No.	98625-26-4
Molecular Formula	C22H26N2O6
Molecular Weight	414.45 g/mol
Synonyms	(S)-(-)-Methyl 2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-1,4-dihydropyridine-3-carboxylate; (S)-Bay K 8644; S(-)-Methyl 1,4-dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylate; (S)-1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylic acid methyl ester; S(-)-Enantiomer of Bay K 8644; L-type Calcium Channel Agonist (S-form); S-BAYK8644
EINECS	Contact for details

Quality Control

Our S(-)-Bay K 8644 is manufactured under strict quality control protocols to ensure high enantiomeric purity and chemical integrity, suitable for sensitive research applications. Each batch is analyzed using advanced chromatographic and spectroscopic techniques, including chiral HPLC, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing assay, enantiomeric excess, and impurity profiles is provided with every shipment to guarantee traceability and compliance with your research specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; ensure the container is sealed tightly after each use to minimize exposure to atmospheric moisture and light.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% (S-enantiomer)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.