Description

5'-Des-o-Methylhomoharringtonine is a semi-synthetic alkaloid derivative of the natural compound homoharringtonine. This compound is of significant interest in pharmaceutical research and development due to its potent biological activity. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and synthesis of novel therapeutic agents, particularly in the fields of oncology and antiviral research.

Application

• Pharmaceutical Research & Development: Serves as a key intermediate or reference standard in the synthesis and study of novel anticancer agents.
• Biochemical Research: Used as a potent tool compound in molecular biology to study protein synthesis inhibition and apoptosis mechanisms.
• Reference Standard: Employed as a high-purity analytical standard for quality control and method development in pharmaceutical analysis (HPLC, LC-MS).
• Preclinical Studies: Utilized in in vitro and in vivo models to investigate pharmacokinetics, efficacy, and toxicity profiles.
• Process Chemistry: Acts as a critical intermediate for the scalable synthesis of more complex harringtonine analogues.
• Academic Research: Supports fundamental chemical and pharmacological studies in university and institutional laboratories.

Basic Information

Product Name	5'-Des-o-Methylhomoharringtonine
CAS No.	98599-84-9
Molecular Formula	C₂₈H₃₇NO₈
Molecular Weight	515.60 g/mol
Synonyms	5'-Des-O-methylhomoharringtonine; 5'-Des-O-methyl-HHT; NSC 329680; Harringtonine derivative; Cephalotaxine ester; Homoharringtonine analogue; 5'-Demethylhomoharringtonine
EINECS	Contact for details

Quality Control

Our 5'-Des-o-Methylhomoharringtonine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by spectroscopic methods (IR, NMR, MS), and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with research-grade specifications. Certificates are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment. For long-term storage, consider desiccant use and inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.