Description

5-Fluoro-2-Methylbenzenesulfonyl Fluoride is a versatile and highly reactive sulfonyl fluoride derivative, serving as a critical building block in advanced organic synthesis. Its primary value lies in its role as a selective reagent for the synthesis of sulfonamides and sulfonate esters, which are key motifs in pharmaceuticals and agrochemicals. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and material science industries seeking to introduce the sulfonyl fluoride functional group for further derivatization or as a handle for chemical biology applications like activity-based protein profiling.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds containing sulfonamide or sulfonate functional groups.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the sulfonyl fluoride moiety imparts specific biological activity.
• Chemical Biology Probe: Utilized in activity-based protein profiling (ABPP) as a reactive handle to label and study serine hydrolases and other enzymes in complex biological systems.
• Material Science Research: Employed in the creation of specialty polymers and advanced materials, where it can act as a cross-linking agent or introduce specific surface functionalities.
• Organic Synthesis Reagent: Serves as a versatile electrophile in nucleophilic substitution reactions for the efficient introduction of sulfonyl groups.
• Fluorination Agent: Acts as a source of fluorine in specific synthetic transformations to create carbon-fluorine bonds.

Basic Information

Product Name	5-Fluoro-2-Methylbenzenesulfonyl Fluoride
CAS No.	98566-96-2
Molecular Formula	C7H6F2O2S
Molecular Weight	192.18 g/mol
Synonyms	2-Methyl-5-fluorobenzenesulfonyl fluoride; 5-Fluoro-o-toluenesulfonyl fluoride; 1-Fluoro-2-methyl-5-sulfonylfluoridebenzene; 2-Methyl-5-fluorophenylsulfonyl fluoride; 5-Fluoro-2-methylphenylsulfonyl fluoride; Benzenesulfonyl fluoride, 5-fluoro-2-methyl-; (5-Fluoro-2-methylphenyl)sulfonyl fluoride
EINECS	Contact for details

Quality Control

Our 5-Fluoro-2-Methylbenzenesulfonyl Fluoride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and industrial synthesis. Each lot is analyzed using advanced chromatographic and spectroscopic techniques. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.