Description

D,L-Buthionine Sulfoxide is a critical biochemical reagent and a key intermediate in the synthesis of glutathione pathway modulators. Its primary value lies in its role as a potent inhibitor of glutathione synthesis, making it an essential tool for research in oxidative stress, cancer biology, and cellular metabolism. This compound is primarily needed by pharmaceutical R&D laboratories, academic research institutions, and manufacturers of high-purity biochemicals for diagnostic applications.

Application

• Biochemical Research: Used as a selective inhibitor of γ-glutamylcysteine synthetase to deplete intracellular glutathione levels in cell culture and animal studies.
• Cancer Research: Employed to sensitize tumor cells to chemotherapy and radiation therapy by compromising cellular antioxidant defenses.
• Oxidative Stress Studies: A fundamental tool for investigating the role of glutathione in protecting cells from reactive oxygen species (ROS) and free radical damage.
• Neurodegenerative Disease Models: Used in research models for Parkinson's, Alzheimer's, and other diseases where oxidative stress is a contributing factor.
• Pharmaceutical Intermediate: Serves as a key synthetic precursor for more complex glutathione analogs and related therapeutic candidates.
• Diagnostic Reagent Manufacturing: Incorporated into kits and assays designed to measure glutathione levels, oxidative stress markers, and related enzyme activities.

Basic Information

Product Name	D,L-Buthionine Sulfoxide
CAS No.	98487-33-3
Molecular Formula	C8H17NO3S
Molecular Weight	207.29 g/mol
Synonyms	DL-Buthionine Sulfoxide; BSO; (RS)-Buthionine Sulfoxide; DL-2-Amino-4-(butylsulfinyl)butyric Acid; (±)-Buthionine Sulfoxide; Buthionine Sulfoxide (DL-form); NSC 326231; L-Buthionine-(R,S)-sulfoxide
EINECS	Contact for details

Quality Control

Our D,L-Buthionine Sulfoxide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and pharmaceutical applications. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.