Description

4-Epitetrodotoxin is a specific stereoisomer of the potent neurotoxin tetrodotoxin, a sodium channel blocker of significant scientific interest. This compound is a critical reference standard and research tool for neuropharmacological studies and toxicological analysis. It is primarily utilized by researchers and quality control laboratories in the pharmaceutical, biotechnology, and analytical chemistry sectors for method development, calibration, and investigative studies into neuronal signaling and toxin mechanisms.

Application

• Neuroscience Research: As a selective sodium channel blocker for studying neuronal excitability, action potential generation, and pain signaling pathways.
• Pharmacological Reference Standard: Used in the calibration of analytical instruments (HPLC, LC-MS) for the quantification of tetrodotoxin and its analogs in various matrices.
• Toxicology and Safety Testing: Employed as an analytical standard in forensic and food safety labs to detect and quantify tetrodotoxin contamination in pufferfish and other marine organisms.
• Drug Discovery & Development: Serves as a molecular tool for screening and validating new compounds targeting voltage-gated sodium channels, relevant for pain management, anesthesia, and cardiac arrhythmia research.
• Biochemical Assay Development: Used in developing and validating cell-based or biochemical assays that monitor sodium channel activity.
• Academic Research: Fundamental studies in universities and research institutes exploring ion channel structure, function, and the biosynthesis of natural toxins.

Basic Information

Product Name	4-Epitetrodotoxin
CAS No.	98242-82-1
Molecular Formula	C11H17N3O8
Molecular Weight	319.27 g/mol
Synonyms	4-epi-TTX; 4-Epi-tetrodotoxin; Tetrodotoxin, 4-epimer; (4S)-4,9-Anhydro-10-[(1S,2S,6S,8S,9R)-2,9-dihydroxy-8-(hydroxymethyl)-1,6-imino-3,7-dioxa-2-azabicyclo[4.3.0]nonan-5-yl]-10-deoxy-1,2,3,4,5,6,7,8-octahydro-6-(hydroxymethyl)quinazolin-8-ol; 4-Epitetrodotoxin (4-epi-TTX)
EINECS	Contact for details

Quality Control

Our 4-Epitetrodotoxin is produced and handled under strict quality management protocols to ensure the highest standards of purity and identity for research applications. Each batch is thoroughly characterized using advanced analytical techniques including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. Due to its hygroscopic nature, the container should be kept sealed in a desiccated environment to prevent moisture absorption. For long-term storage, consider storing under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.