Description

Hydroxynefazodone is a key pharmaceutical intermediate and reference standard of significant interest in research and development. This compound is primarily utilized in the synthesis and analytical characterization of active pharmaceutical ingredients (APIs) within the neuropharmacology domain. It is essential for pharmaceutical manufacturers, contract research organizations (CROs), and academic institutions focused on central nervous system (CNS) drug discovery and quality control.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel therapeutic agents targeting specific neurological pathways.
• Analytical Reference Standard: Used for method development, validation, and quality control (QC) testing in HPLC, LC-MS, and other chromatographic systems.
• Metabolite Studies: Employed in pharmacokinetic and pharmacodynamic research to study drug metabolism and biotransformation.
• Impurity Profiling: Serves as a certified reference material for identifying and quantifying related substances in bulk drug substances and finished dosage forms.
• Biochemical Research: A tool for investigating receptor binding affinity and enzymatic activity in preclinical studies.
• GMP Manufacturing: Supports the production of APIs under current Good Manufacturing Practice (cGMP) guidelines for clinical trial materials and commercial supply.

Basic Information

Product Name	Hydroxynefazodone
CAS No.	98159-82-1
Molecular Formula	C25H32ClN5O3
Molecular Weight	502.01 g/mol
Synonyms	2-[3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl]-5-ethyl-2,4-dihydro-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one; Hydroxy Nefazodone; Nefazodone Hydroxy Metabolite; OH-Nefazodone; 1-(3-Chlorophenyl)-4-[3-(5-ethyl-4-(2-phenoxyethyl)-4H-1,2,4-triazol-3-yl)propyl]piperazine; CP-448,187
EINECS	Contact for details

Quality Control

Our Hydroxynefazodone is manufactured and tested under a strict quality management system. Each batch is subjected to comprehensive analytical testing, including identity confirmation, purity assay, and impurity profiling, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data (HPLC/LC-MS) are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5% w/w
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.