Description

Pyroglutamyl Diazomethyl Ketone is a specialized biochemical building block and a key intermediate in advanced organic synthesis. This compound is valued for its reactive diazomethyl ketone functional group, which enables precise carbon-carbon bond formation and peptide chain extension. It is primarily utilized by research institutions and pharmaceutical development teams working on novel peptide-based therapeutics, enzyme inhibitors, and complex molecular probes.

Application

• Peptide Synthesis Intermediate: A crucial building block for the solid-phase and solution-phase synthesis of complex peptides and peptidomimetics.
• Pharmaceutical Research: Used in the development and scale-up of active pharmaceutical ingredients (APIs), particularly those targeting neurological and metabolic disorders.
• Protease Inhibitor Development: Serves as a precursor for creating potent and selective inhibitors of various proteolytic enzymes.
• Bioconjugation Chemistry: Employed in the site-specific labeling and modification of proteins and other biomolecules for diagnostic and therapeutic applications.
• Chemical Biology Probes: Utilized to synthesize activity-based probes for studying enzyme function and mechanism in biological systems.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic chemistry and medicinal chemistry research programs.

Basic Information

Product Name	Pyroglutamyl Diazomethyl Ketone
CAS No.	98151-77-0
Molecular Formula	C7H9N3O3
Molecular Weight	183.16 g/mol
Synonyms	5-Oxo-L-prolyl Diazomethyl Ketone; L-Pyroglutamyl Diazomethyl Ketone; (S)-5-Oxopyrrolidine-2-carboxylic Acid Diazomethyl Ketone; 2-(Diazoacetyl)-L-pyroglutamic Acid; PDK; Pyroglutamic Acid Diazomethyl Ketone; 5-Oxo-L-proline Diazomethyl Ketone; N-(Diazoacetyl)-L-pyroglutamic Acid
EINECS	Contact for details

Quality Control

Our Pyroglutamyl Diazomethyl Ketone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its light-sensitive nature, handling should be performed under subdued lighting. For long-term storage, consider keeping the container under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.