Description

3-Chloro-2-Hydroxypropylmercapturic Acid is a key mercapturic acid metabolite, serving as a critical biomarker for monitoring human exposure to specific industrial chemicals and environmental pollutants. Its primary value lies in providing definitive analytical data for toxicological and occupational health studies. This compound is essential for research and diagnostic laboratories in the pharmaceutical, environmental safety, and industrial hygiene sectors.

Application

• Biomarker Analysis: Used as a reference standard in LC-MS/MS and HPLC methods to quantify human exposure to epichlorohydrin and related propylene oxide derivatives.
• Toxicology Research: A vital tool for studying metabolic pathways, bioactivation, and detoxification processes of halogenated hydrocarbons in biological systems.
• Occupational Health Monitoring: Enables the development and validation of assays for biological monitoring programs in industries handling chlorinated epoxides or allyl chloride.
• Environmental Exposure Assessment: Supports epidemiological studies by providing a measurable endpoint for assessing population-level exposure to specific environmental contaminants.
• Method Development & Validation: Serves as a high-purity calibrant and quality control material for analytical laboratories establishing new diagnostic or research protocols.
• Pharmaceutical Impurity Profiling: Can be utilized in the characterization and control of potential genotoxic impurities (PGIs) in active pharmaceutical ingredient (API) manufacturing.

Basic Information

Product Name	3-Chloro-2-Hydroxypropylmercapturic Acid
CAS No.	97729-49-2
Molecular Formula	C8H14ClNO5S
Molecular Weight	279.72 g/mol
Synonyms	N-Acetyl-S-(3-chloro-2-hydroxypropyl)-L-cysteine; 3-Chloro-2-hydroxypropylmercapturic acid; S-(3-Chloro-2-hydroxypropyl)-N-acetylcysteine; 3-Chloro-2-hydroxypropyl-MA; CHPMA; N-Acetyl-S-(3-chloro-2-hydroxypropyl)cysteine; (2R)-2-Acetamido-3-[(3-chloro-2-hydroxypropyl)sulfanyl]propanoic acid
EINECS	Contact for details

Quality Control

Our 3-Chloro-2-Hydroxypropylmercapturic Acid is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research and diagnostic applications. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.