Description

DL-Buthionine-Sulfoximine (BSO) is a potent, cell-permeable, and irreversible inhibitor of γ-glutamylcysteine synthetase, the rate-limiting enzyme in glutathione biosynthesis. This action makes it a critical research tool for studying oxidative stress, cellular detoxification pathways, and the role of glutathione in chemoresistance. It is essential for researchers and developers in pharmaceutical R&D, oncology research, and biochemistry who require a reliable compound to modulate intracellular glutathione levels and investigate related disease mechanisms.

Application

• Biomedical Research: A fundamental tool for depleting intracellular glutathione (GSH) to study oxidative stress, apoptosis, and redox signaling in cell culture and animal models.
• Oncology & Cancer Research: Used to sensitize tumor cells to chemotherapy, radiation therapy, and other anticancer agents by inhibiting GSH-mediated detoxification and resistance mechanisms.
• Neurodegenerative Disease Studies: Applied in research models for Parkinson's, Alzheimer's, and other disorders where oxidative damage and glutathione metabolism are implicated.
• Toxicology & Pharmacology: Employed to investigate the role of glutathione in drug metabolism, hepatotoxicity, and the cellular response to environmental toxins.
• Biochemical Assay Development: Serves as a key reference standard and active component in assays designed to measure glutathione synthesis and related enzymatic activity.

Basic Information

Product Name	DL-Buthionine-Sulfoximine
CAS No.	97590-40-4
Molecular Formula	C8H18N2O3S
Molecular Weight	222.31 g/mol
Synonyms	BSO; Buthionine Sulfoximine; DL-BSO; (RS)-Buthionine Sulfoximine; L-Buthionine-(S,R)-sulfoximine; NSC 326231; γ-Glutamylcysteine Synthetase Inhibitor; Glutathione Synthesis Inhibitor
EINECS	Contact for details

Quality Control

Our DL-Buthionine-Sulfoximine is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for critical research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation (IR, NMR), and residual solvent analysis. Certificates of Analysis (COA) detailing all specifications and test results are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.