Description

o-Methylsuccinyl-Alanyl-Alanyl-Prolyl-Borophenylalanine is a specialized peptide boronic acid derivative, a class of compounds known for their potent and selective protease inhibition. This molecule matters for its role as a key intermediate or active pharmaceutical ingredient (API) in the development of novel therapeutic agents, particularly proteasome inhibitors. It is essential for pharmaceutical R&D teams and manufacturers focused on oncology, inflammatory diseases, and other conditions where targeted protein degradation is a therapeutic strategy.

Application

• Pharmaceutical Intermediate: Critical building block in the synthesis of advanced proteasome inhibitor drugs.
• Research & Development: Used in biochemical and pharmacological studies to investigate proteasome function and inhibition mechanisms.
• Preclinical Development: Serves as a reference standard or active component in formulation studies for new drug candidates.
• Bioconjugation: Potential use in creating targeted drug conjugates due to its reactive boronic acid moiety.
• Enzyme Inhibition Studies: Tool compound for studying the specificity and kinetics of serine proteases.

Basic Information

Product Name	o-Methylsuccinyl-Alanyl-Alanyl-Prolyl-Borophenylalanine
CAS No.	97590-10-8
Molecular Formula	C24H34BN4O8
Molecular Weight	509.36 g/mol
Synonyms	Bortezomib Intermediate; MG-262; PS-341 Intermediate; [(1R)-3-Methyl-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(1R)-1-(3-Boronophenyl)-3-methylbutyl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxobutyl]boronic Acid; o-MeSucc-Ala-Ala-Pro-BoroPhe; Boronic Acid, [(1R)-3-methyl-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(1R)-1-(3-boronophenyl)-3-methylbutyl]amino]-3-phenyl-1-oxo-2-propan-2-yl]amino]-1-oxo-2-propan-2-yl]amino]-1-oxo-2-propan-2-yl]amino]-1-oxobutyl]-
EINECS	Contact for details

Quality Control

Our o-Methylsuccinyl-Alanyl-Alanyl-Prolyl-Borophenylalanine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, MS), to ensure it meets the high standards required for pharmaceutical development. Certificates of Analysis (COA) detailing specific results for purity, related substances, and residual solvents are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.