Description

S-(Phenylsulfonyl)Glutathione is a chemically modified derivative of the endogenous tripeptide glutathione, featuring a phenylsulfonyl moiety attached to the sulfur atom. This modification makes it a valuable biochemical tool and a key intermediate in the study of redox biology, enzyme inhibition, and cellular detoxification pathways. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors for developing analytical methods, probing enzyme mechanisms, and synthesizing more complex bioactive molecules.

Application

• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, particularly for glutathione S-transferases (GSTs) and other redox-related enzymes.
• Pharmaceutical Intermediates: Serves as a key synthetic building block for the development of novel drug candidates targeting oxidative stress and inflammation.
• Proteomics & Metabolomics: Acts as a standard or reagent in mass spectrometry-based analyses to study post-translational modifications and metabolic pathways involving glutathionylation.
• Antioxidant Mechanism Studies: Employed to investigate the role of glutathione derivatives in cellular defense against reactive oxygen and nitrogen species.
• Diagnostic Kit Development: Utilized in the formulation of assay kits for measuring GST activity or glutathione-related biomarkers in clinical and research settings.

Basic Information

Product Name	S-(Phenylsulfonyl)Glutathione
CAS No.	97512-84-0
Molecular Formula	C₁₆H₂₁N₃O₈S₂
Molecular Weight	447.48 g/mol
Synonyms	Glutathione S-(phenylsulfonate); S-Phenylsulfonylglutathione; γ-Glu-Cys(SO₂Ph)-Gly; L-γ-Glutamyl-S-(phenylsulfonyl)-L-cysteinylglycine; (2S)-2-Amino-4-{[(1R)-1-[(carboxymethyl)carbamoyl]-2-[(phenylsulfonyl)sulfanyl]ethyl]carbamoyl}butanoic acid; Phenylsulfonyl glutathione; GST Inhibitor (S-(Phenylsulfonyl)Glutathione)
EINECS	Contact for details

Quality Control

Our S-(Phenylsulfonyl)Glutathione is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive). Allow the container to reach room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.