Description

4-Amino-2,2,6,6-Tetramethylpiperidine-D17, 1-15N-1-Oxyl is a deuterated and 15N-labeled nitroxide radical derivative of TEMPAMINE, a key spin probe and spin label. This isotopically enriched compound is essential for advanced Electron Paramagnetic Resonance (EPR) and Dynamic Nuclear Polarization (DNP) NMR spectroscopy, providing superior spectral resolution and sensitivity. It is primarily used by research scientists and process developers in pharmaceutical R&D, materials science, and structural biology for mechanistic studies, protein dynamics, and polymer characterization.

Application

• Spin Labeling in Structural Biology: Site-directed spin labeling (SDSL) of proteins and nucleic acids for studying conformational changes, folding, and macromolecular interactions via EPR spectroscopy.
• Dynamic Nuclear Polarization (DNP) Agent: Used as a polarizing agent in DNP-NMR to achieve significant signal enhancement, enabling the study of surfaces, materials, and biological samples at low concentrations.
• Polymer & Materials Science Research: Acts as a stable radical probe for investigating polymerization kinetics, radical trapping, polymer chain dynamics, and degradation mechanisms.
• Antioxidant & Redox Mechanism Studies: Serves as a model nitroxide radical for probing antioxidant activity, redox cycling, and free radical scavenging processes in chemical and biological systems.
• Magnetic Resonance Imaging (MRI) Contrast Agent Development: Utilized in the research and development of novel, responsive contrast agents based on paramagnetic nitroxides.
• Stable Isotope-Labeled Standard: Employed as an internal standard in mass spectrometry for the quantitative analysis of related amine compounds or degradation products.

Basic Information

Item	Detail
Product Name	4-Amino-2,2,6,6-Tetramethylpiperidine-D17, 1-15N-1-Oxyl
CAS No.	97461-87-5
Molecular Formula	C9D17H2^15N2O
Molecular Weight	~190.3 g/mol
Synonyms	4-Amino-TEMPO-d17, 1-15N; 4-Amino-2,2,6,6-tetramethylpiperidine-1-oxyl-^15N,d17; 4-Amino-TEMPO (^15N, d17); 4-AT-d17, 1-15N-1-oxyl; 4-Amino-2,2,6,6-tetramethyl-1-piperidinyloxy-d17, 1-15N; 4-AT-d17 (^15N labeled); Perdeuterated 4-Amino-TEMPO-^15N; 4-Aminopiperidinooxy-d17, 1-15N
EINECS	Contact for details

Quality Control

Every batch of 4-Amino-2,2,6,6-Tetramethylpiperidine-D17, 1-15N-1-Oxyl is produced and analyzed under strict quality management protocols. We guarantee high isotopic purity (chemical and isotopic) verified by advanced analytical techniques including NMR (1H, 13C, 2H), mass spectrometry, and EPR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing purity, isotopic enrichment, and radical concentration is provided with each shipment to ensure traceability and compliance with your research specifications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store the product at 2-8°C under an inert atmosphere (argon or nitrogen) to minimize oxidation and radical degradation. The container should be kept in a cool, dry, and well-ventilated place away from heat sources and incompatible materials.

Specification

Item	Specification
Appearance	Orange to red crystalline powder or solid
Identification (EPR)	Complies
Identification (NMR)	Complies
Purity (HPLC)	≥ 98.0%
Isotopic Purity (^15N)	≥ 98 atom %
Deuterium Enrichment (D)	≥ 98 atom % D
Radical Concentration (EPR)	≥ 95% of theoretical
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.