Description

Dehydroepiandrosterone-D5 (Dhea-D5) (2,2,3,4,4-D5) is a stable isotope-labeled analog of the endogenous steroid hormone dehydroepiandrosterone (DHEA), where five hydrogen atoms are replaced by deuterium. This compound is a critical tool for quantitative bioanalytical research, enabling precise and accurate measurement of DHEA levels in complex biological matrices. It is primarily utilized by pharmaceutical R&D laboratories, clinical research organizations, and academic institutions engaged in endocrinology, metabolomics, and pharmacokinetic studies.

Application

• Internal Standard for LC-MS/MS: Serves as a high-purity, non-interfering internal standard for the quantitative analysis of endogenous DHEA in serum, plasma, and tissue samples using liquid chromatography-tandem mass spectrometry (LC-MS/MS).
• Metabolic Pathway Tracing: Used in deuterium-labeling studies to investigate the metabolic fate, biotransformation pathways, and pharmacokinetics of DHEA in preclinical and clinical research.
• Biomarker Assay Development & Validation: Essential for developing and validating robust, GLP-compliant bioanalytical methods to quantify DHEA as a biomarker in diagnostic and therapeutic monitoring applications.
• Endocrinology and Steroid Research: Supports fundamental and applied research into adrenal function, aging, and steroid hormone-related disorders by providing a reliable reference compound for assay calibration.
• Pharmaceutical Quality Control: Employed in the quality control testing of pharmaceutical formulations containing DHEA or its derivatives to ensure accurate potency assessment.

Basic Information

Item	Details
Product Name	Dehydroepiandrosterone-D5 (Dhea-D5) (2,2,3,4,4-D5)
CAS No.	97453-25-3
Molecular Formula	C19H23D5O2
Molecular Weight	293.46 g/mol (approx.)
Synonyms	3β-Hydroxy-5-androsten-17-one-2,2,3,4,4-d5; DHEA-d5; 5-Dehydroepiandrosterone-d5; Androstenolone-d5; Prasterone-d5; (3β)-3-Hydroxyandrost-5-en-17-one-2,2,3,4,4-d5; Dehydroisoandrosterone-d5
EINECS	Contact for details

Quality Control

Our Dehydroepiandrosterone-D5 is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing key parameters such as isotopic enrichment, chemical purity by HPLC, and identity confirmation. We adhere to relevant industry standards for research chemicals, ensuring reliable performance and traceability for your critical studies.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at -20°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity (by HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.