Description

9,11-Dimethylmethano-11,12-Methano 16-(3-Iodo-4-Hydroxyphenyl)-13,14-Dihydro-13-Aza-15-Tetranorthromboxane A2 is a sophisticated synthetic analog of thromboxane A2, a key bioactive eicosanoid. This compound is of significant value as a high-potency research chemical and a critical tool for probing thromboxane receptor (TP receptor) pharmacology and signaling pathways. It is primarily utilized by pharmaceutical R&D teams and academic research institutions focused on cardiovascular biology, inflammation, and hemostasis.

Application

• Pharmacological Research: Acts as a potent thromboxane A2 mimetic for studying TP receptor activation, signal transduction, and downstream cellular effects.
• Cardiovascular Disease Models: Used in vitro and in vivo to induce platelet aggregation, vasoconstriction, and to model thrombotic and ischemic conditions.
• Drug Discovery & Screening: Serves as a reference standard and agonist in high-throughput screening (HTS) assays to identify and characterize novel TP receptor antagonists.
• Biochemical Pathway Analysis: A key tool for elucidating the role of thromboxane pathways in inflammation, atherosclerosis, and bronchoconstriction.
• Reference Standard: Employed in analytical method development and validation (e.g., HPLC, LC-MS) for quality control in related API synthesis.
• Academic & Institutional Research: Fundamental research into eicosanoid biology, receptor-ligand interactions, and the development of therapeutic interventions.

Basic Information

Product Name	9,11-Dimethylmethano-11,12-Methano 16-(3-Iodo-4-Hydroxyphenyl)-13,14-Dihydro-13-Aza-15-Tetranorthromboxane A2
CAS No.	97228-80-3
Molecular Formula	C23H28INO4
Molecular Weight	533.38 g/mol
Synonyms	9,11-Dimethylmethano-11,12-methano-16-(3-iodo-4-hydroxyphenyl)-13,14-dihydro-13-aza-15-tetranor-thromboxane A2; I-BOP; [1S-[1α,2α(Z),3α(1E,3S*),4α]]-7-[3-[3-Hydroxy-4-(iodophenoxy)-1-butenyl]-7-oxabicyclo[2.2.1]hept-2-yl]-5-heptenoic Acid; Thromboxane A2 Agonist I-BOP; TP Receptor Agonist I-BOP; (Z)-7-[(1S,2S,3S,5R)-2-[(1E,3S)-3-Hydroxy-4-(3-iodo-4-hydroxyphenoxy)-1-butenyl]-3,5-dihydroxycyclopentyl]-5-heptenoic Acid; I-BOP Thromboxane Mimetic
EINECS	Contact for details

Quality Control

Our 9,11-Dimethylmethano-11,12-Methano 16-(3-Iodo-4-Hydroxyphenyl)-13,14-Dihydro-13-Aza-15-Tetranorthromboxane A2 is produced under strict quality management systems. Each batch undergoes comprehensive analytical characterization to ensure identity, purity, and stability, meeting the exacting standards required for pharmaceutical research. Certificates of Analysis (COA) detailing purity (by HPLC), identity confirmation (NMR, IR), and impurity profiles are provided to guarantee reliable and reproducible research outcomes.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere. Allow the product to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. Keep the container in a dry, well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.