Description

cis-A-Hydroxy Tamoxifen is a key intermediate and active metabolite in the synthesis and metabolic pathway of the selective estrogen receptor modulator (SERM) Tamoxifen. This compound is of significant value for pharmaceutical research and development, particularly in the study of breast cancer therapeutics and endocrine pharmacology. It is primarily required by pharmaceutical manufacturers, advanced research institutions, and contract development and manufacturing organizations (CDMOs) engaged in oncology drug development and metabolic studies.

Application

• Pharmaceutical Intermediate: Critical synthesis intermediate for the production of Tamoxifen and its related analogs.
• Metabolite Reference Standard: Used as a certified reference material (CRM) for the quantification of Tamoxifen metabolites in pharmacokinetic and bioanalytical studies.
• Biochemical Research: Employed in vitro and in vivo studies to investigate the mechanism of action, efficacy, and side-effect profiles of SERMs.
• Drug Discovery & Development: Serves as a building block for the development of new estrogen receptor-targeting compounds with potential therapeutic applications.
• Quality Control Testing: Utilized by QC laboratories in pharmaceutical production to validate analytical methods and ensure batch consistency.

Basic Information

Product Name	cis-A-Hydroxy Tamoxifen
CAS No.	97170-41-7
Molecular Formula	C26H29NO2
Molecular Weight	387.52 g/mol
Synonyms	(Z)-4-Hydroxytamoxifen; (Z)-1-[4-[2-(Dimethylamino)ethoxy]phenyl]-1,2-diphenyl-1-buten-4-ol; cis-4-Hydroxytamoxifen; Afimoxifene (cis-isomer); Metabolite BX; ICI 79280; Z-4-Hydroxytamoxifen; (Z)-Endoxifen
EINECS	Contact for details

Quality Control

Our cis-A-Hydroxy Tamoxifen is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by spectroscopic methods (IR, NMR), and residual solvent analysis to ensure it meets high-purity standards suitable for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided for traceability and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.