Description

K-252A is a potent, cell-permeable, and selective inhibitor of protein kinase C (PKC) and other serine/threonine kinases, widely recognized in biochemical and pharmacological research. This high-purity compound is essential for studying intracellular signaling pathways, cell proliferation, and neuronal function. It is a critical research tool for scientists and organizations in the pharmaceutical, biotechnology, and academic sectors focused on neuroscience, oncology, and signal transduction research.

Application

• Biochemical Research: Used as a selective inhibitor to study the role of Protein Kinase C (PKC) and related kinases in cellular signaling cascades.
• Neuroscience Studies: Applied in research on neurotrophin signaling, neuronal survival, differentiation, and synaptic plasticity.
• Cancer Research: Investigated for its effects on tumor cell growth, apoptosis, and the modulation of oncogenic pathways.
• Pharmacology & Drug Discovery: Serves as a reference standard and a key tool compound for validating assays and screening for novel kinase inhibitors.
• Cell Biology: Utilized to elucidate mechanisms of cell cycle regulation, secretion, and other kinase-dependent cellular processes.

Basic Information

Product Name	K-252A
CAS No.	97161-97-2
Molecular Formula	C₂₇H₂₁N₅O₅
Molecular Weight	495.49 g/mol
Synonyms	9-Hydroxy-9-methoxycarbonyl-8-methyl-2,3,9,10-tetrahydro-8H-8,13b-epoxy-1H,12H-diisoquino[2,1-g:1',2'-k]pyrrolo[3,4-h][1,6]oxadiazacyclopentadecine-1,12(2H,13H)-dione; K252a; SF 2370; Antibiotic K 252a; Staurosporine aglycone; Microbial alkaloid K-252a
EINECS	Contact for details

Quality Control

Our K-252A is produced under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. The product is light-sensitive (store away from light). Allow the vial to warm to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (HPLC/IR)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.