Description

N(Alpha)-(1-Adamantanesulfonyl)-N(Epsilon)-(4-Carboxybenzoyl)Lysyl-Alanyl-Valinal CAS NO 97143-05-0 is a synthetic, modified peptide aldehyde designed as a potent and selective inhibitor of proteasome activity. This compound is a critical research tool for studying cellular protein degradation pathways, apoptosis, and inflammation. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in drug discovery and biochemical mechanism studies.

Application

• Proteasome Research: Serves as a key biochemical tool for the specific inhibition of the chymotrypsin-like activity of the 20S proteasome complex in in vitro and cell-based assays.
• Drug Discovery & Development: Used as a reference standard and pharmacophore model in the design and screening of novel anti-cancer and anti-inflammatory therapeutic agents targeting the ubiquitin-proteasome pathway.
• Apoptosis Studies: Employed to induce programmed cell death in research models to investigate signaling pathways and identify potential therapeutic targets.
• Inflammation & Immunology Research: Applied in studies to understand the role of NF-κB activation and cytokine regulation, which are controlled by proteasome-mediated degradation of inhibitory proteins.
• Biochemical Reagent: Used as a high-purity intermediate or active pharmaceutical ingredient (API) in the synthesis of more complex molecular probes or labeled derivatives for advanced research.

Basic Information

Item	Details
Product Name	N(Alpha)-(1-Adamantanesulfonyl)-N(Epsilon)-(4-Carboxybenzoyl)Lysyl-Alanyl-Valinal
CAS No.	97143-05-0
Molecular Formula	C33H48N4O8S
Molecular Weight	660.82 g/mol
Synonyms	N(α)-Adaman-1-ylsulfonyl-N(ε)-(4-carboxybenzoyl)-Lys-Ala-Valinal; Proteasome Inhibitor I; PSI; Cbz-LLL-VS; (2S)-2-[[(2S)-2-[[(2S)-6-[[(4-Carboxybenzoyl)amino]-2-[[(tricyclo[3.3.1.13,7]dec-1-yl)sulfonyl]amino]hexanoyl]amino]propanoyl]amino]-3-methylbutanal; N(α)-1-Adamantanesulfonyl-N(ε)-(4-carboxybenzoyl)-L-lysyl-L-alanyl-L-valinal; Adoa-Lys(Cbz)-Ala-Val-H
EINECS	Contact for details

Quality Control

Our N(Alpha)-(1-Adamantanesulfonyl)-N(Epsilon)-(4-Carboxybenzoyl)Lysyl-Alanyl-Valinal is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and chiral analysis to ensure stereochemical integrity. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to prevent condensation and hydrolysis. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.