Description

Poly Ic-Polylysine Carboxymethyl Dextran is a synthetic, branched polymer conjugate designed for advanced biomedical and biotechnological applications. This compound matters for its unique ability to combine the immunostimulatory properties of polyinosinic-polycytidylic acid (poly I:C) with the cationic and biodegradable characteristics of polylysine and carboxymethyl dextran. It is primarily needed by researchers and manufacturers in the pharmaceutical and life sciences sectors for developing novel vaccine adjuvants, drug delivery systems, and immunotherapies.

Application

• Vaccine Adjuvant Development: Used as an immunostimulant to enhance the efficacy of prophylactic and therapeutic vaccines.
• Drug Delivery Carrier: Serves as a biodegradable vector for the targeted delivery of nucleic acids (e.g., siRNA, mRNA) and proteins.
• Cancer Immunotherapy: Employed in research for stimulating innate immune responses against tumors.
• Immunology Research: A key tool for studying Toll-like receptor 3 (TLR3) signaling pathways and antiviral responses.
• Bioconjugation & Surface Modification: Used to functionalize nanoparticles or biomaterial surfaces to impart immune-modulatory properties.
• Cell Culture & Transfection Reagent: Acts as a complexing agent to improve the transfection efficiency of genetic material into cells.

Basic Information

Product Name	Poly Ic-Polylysine Carboxymethyl Dextran
CAS No.	97127-12-3
Molecular Formula	(C6H10O5)n · (C6H12N2O)m · (C10H13N4O7P · C9H14N3O7P)p
Molecular Weight	Variable (Polymer)
Synonyms	Poly I:C-Polylysine-Carboxymethyl Dextran; Polyinosinic-Polycytidylic Acid-Polylysine-Carboxymethyl Dextran Conjugate; Poly I:C-PLL-CMD; TLR3 Agonist Conjugate; Carboxymethyl Dextran Poly I:C Polylysine; Immunostimulatory Polymer Conjugate; Poly(I:C)/Polylysine/Carboxymethyl Dextran Complex
EINECS	Contact for details

Quality Control

Our Poly Ic-Polylysine Carboxymethyl Dextran is produced under controlled conditions to ensure batch-to-batch consistency for research and development. Each lot undergoes rigorous quality testing, including analysis of polymer composition, conjugate ratio, and biological activity. Certificates of Analysis (COA) detailing specifications for research-grade material are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption. For long-term stability, store desiccated.

Specification

Item	Specification
Appearance	White to off-white solid or lyophilized powder
Identification (IR)	Conforms to structure
Conjugate Ratio (Poly I:C Content)	By UV-Vis Spectroscopy
Polylysine Substitution Degree	By TNBS Assay or NMR
Carboxymethyl Substitution Degree	By Titration
Molecular Weight Distribution	By Size Exclusion Chromatography (SEC)
Endotoxin Level	< 1.0 EU/mg (for in vitro use)
Biological Activity (TLR3 Activation)	Cell-based reporter assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.