Description

o-Dansyl-L-Tyrosine Free Acid is a high-purity, fluorescent-labeled derivative of the amino acid L-tyrosine. This compound is a critical reagent for fluorescence spectroscopy and biochemical research, serving as a sensitive probe for studying enzyme kinetics, protein interactions, and binding sites. It is primarily utilized by research institutions, pharmaceutical R&D departments, and diagnostic kit manufacturers engaged in advanced analytical and life science applications.

Application

• Fluorescence Quenching & Binding Studies: Acts as a sensitive fluorescent probe to investigate protein-ligand interactions, receptor binding affinities, and conformational changes.
• Enzyme Activity Assays: Used as a substrate or competitive inhibitor in assays for proteases, kinases, and phosphatases, enabling real-time monitoring of enzymatic activity.
• Biomolecular Labeling: Serves as a starting material or reference standard for the synthesis of dansyl-labeled peptides, proteins, and other biomolecules.
• Analytical Method Development: Employed as a standard in High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) for method validation and calibration in analytical laboratories.
• Diagnostic Reagent Synthesis: Used in the development and production of fluorescent diagnostic reagents and biosensors.
• Photophysical Research: Studied for its intrinsic photochemical properties to understand energy transfer mechanisms and develop new fluorescent tags.

Basic Information

Product Name	o-Dansyl-L-Tyrosine Free Acid
CAS No.	1252-04-6
Molecular Formula	C21H22N2O5S
Molecular Weight	414.48 g/mol
Synonyms	N-[(5-Dimethylamino-1-naphthyl)sulfonyl]-L-tyrosine; Dansyl-L-tyrosine; 1-Dimethylaminonaphthalene-5-sulfonyl-L-tyrosine; DNS-Tyr-OH; L-Tyrosine, N-[5-(dimethylamino)-1-naphthalenesulfonyl]-; 5-Dimethylaminonaphthalene-1-sulfonyl-L-tyrosine; o-Dansyl-L-Tyrosine; N-Dansyl-L-tyrosine
EINECS	Contact for details

Quality Control

Our o-Dansyl-L-Tyrosine Free Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and specific tests for residual solvents and moisture. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and stored in the dark, preferably under an inert atmosphere for long-term stability.

Specification

Item	Specification
Appearance	Yellow to orange-yellow powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.