Description

m-Maleimidobenzoyl-n-Hydroxysulfosuccinimide Ester is a heterobifunctional crosslinking reagent designed for the stable conjugation of biomolecules. This compound matters for its ability to create robust, site-specific linkages between thiol-containing and amine-containing molecules, forming stable thioether bonds. It is primarily needed by researchers and manufacturers in the fields of bioconjugation, antibody-drug conjugate (ADC) development, and the preparation of diagnostic and therapeutic protein conjugates.

Application

• Antibody-Drug Conjugate (ADC) Linker Chemistry: For the site-specific conjugation of cytotoxic payloads to monoclonal antibodies.
• Protein and Peptide Labeling: Conjugation of fluorescent dyes, enzymes, or other reporter molecules to proteins for assays and diagnostics.
• Immobilization of Biomolecules: Covalent attachment of proteins, antibodies, or peptides to solid supports (e.g., beads, plates, biosensors).
• Polymer-Protein Conjugate Synthesis: Creating PEGylated or other polymer-modified therapeutic proteins to enhance pharmacokinetics.
• Nanoparticle Functionalization: Surface modification of nanoparticles with targeting ligands or proteins for biomedical applications.
• Diagnostic Reagent Development: Production of stable immunoconjugates used in ELISA, lateral flow assays, and other diagnostic platforms.

Basic Information

Product Name	m-Maleimidobenzoyl-n-Hydroxysulfosuccinimide Ester
CAS No.	103848-62-0
Molecular Formula	C15H10N2O9S
Molecular Weight	418.32 g/mol
Synonyms	m-Maleimidobenzoyl-N-hydroxysulfosuccinimide ester; Sulfo-MBS; m-Maleimidobenzoyl sulfosuccinimide ester; 4-(N-Maleimidomethyl)cyclohexane-1-carboxylic acid N-hydroxysulfosuccinimide ester (common mis-assignment); 3-Maleimidobenzoic acid N-hydroxysulfosuccinimide ester; MBS (sulfonated form); Sulfo-Maleimidobenzoyl-N-hydroxysuccinimide ester; Heterobifunctional crosslinker, sulfo-MBS
EINECS	Contact for details

Quality Control

Our m-Maleimidobenzoyl-n-Hydroxysulfosuccinimide Ester is manufactured under strict quality systems to ensure batch-to-batch consistency and high performance in sensitive bioconjugation applications. Each lot undergoes comprehensive analytical testing, including HPLC purity analysis, NMR structural confirmation, and functional activity validation. Certificates of Analysis (COA) detailing all specifications and test results are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in water, DMF, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.