Description

Cyanosafracin B CAS NO 96996-50-8 is a specialized pyrrolobenzodiazepine (PBD) derivative, a class of compounds known for their potent biological activity. This compound is valued for its role as a key synthetic intermediate and a promising scaffold in advanced pharmaceutical research and development. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery of novel anticancer agents and antibody-drug conjugates (ADCs).

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of complex therapeutic molecules, particularly pyrrolobenzodiazepine (PBD) dimers.
• Antibody-Drug Conjugate (ADC) Payload: Used as a potent cytotoxic warhead that can be conjugated to monoclonal antibodies for targeted cancer therapy.
• Oncology Research: Investigated as a core structure in the development of novel DNA-interactive agents for treating various cancers.
• Chemical Biology: Employed as a tool compound to study DNA minor groove binding and its subsequent biological effects.
• Process Development: Used in scaling up and optimizing synthetic routes for next-generation PBD-based therapeutics.

Basic Information

Product Name	Cyanosafracin B
CAS No.	96996-50-8
Molecular Formula	C21H19N5O4
Molecular Weight	405.41 g/mol
Synonyms	(11aS)-8-Cyano-7-methoxy-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one; SJG-136 Intermediate; PBD Monomer; Safracin B derivative; DNA-binding agent intermediate
EINECS	Contact for details

Quality Control

Our Cyanosafracin B is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity, essential for sensitive pharmaceutical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP standards where applicable to support our clients' regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.