Description

Albicidin is a potent, naturally derived antibacterial phytotoxin originally isolated from the plant-pathogenic bacterium *Xanthomonas albilineans*. It exhibits exceptional activity against Gram-negative bacteria—including multidrug-resistant strains—by inhibiting bacterial DNA gyrase and topoisomerase IV through a novel binding mechanism distinct from fluoroquinolones. This makes Albicidin CAS NO 96955-97-4 a high-priority candidate for next-generation antibiotic development and targeted antimicrobial research. It is primarily sought by pharmaceutical R&D laboratories, academic institutions, and biotech companies engaged in novel anti-infective discovery and mechanistic microbiology studies.

Application

• Lead compound in preclinical antibiotic development targeting drug-resistant *E. coli*, *Pseudomonas aeruginosa*, and *Acinetobacter baumannii*
• Tool compound for structural and functional studies of bacterial type II topoisomerases
• Reference standard in HPLC and LC-MS/MS method validation for antimicrobial residue analysis
• Active ingredient in experimental agricultural biocontrol formulations against xylem-limited bacterial pathogens
• Probe molecule in target engagement assays and resistance mechanism profiling
• Component in high-throughput screening libraries for novel gyrase/topoisomerase inhibitors

Basic Information

Product Name	Albicidin
CAS No.	96955-97-4
Molecular Formula	C51H58N10O16
Molecular Weight	1123.08 g/mol
Synonyms	Albicidin A; Albicidin I; Xanthomonadin; Xanthomonas toxin; Albicidin (natural mixture); Albicidin complex; CAS 96955-97-4; Antibiotic albicidin; DNA gyrase inhibitor albicidin; Topoisomerase IV inhibitor albicidin
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. Each batch is verified for identity (HPLC retention time match, IR spectral overlay), assay (≥95.0% by HPLC), and impurity profile (individual impurities ≤0.5%, total impurities ≤3.0%). Testing adheres to ICH Q2(R2) guidelines, and manufacturing follows cGMP-aligned practices suitable for research-grade and early-stage pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store at 2–8 °C under inert atmosphere (argon or nitrogen) to prevent degradation. Due to its hygroscopic nature, maintain low-humidity conditions (<30% RH) and minimize exposure to ambient air during handling.

Specification

Item	Specification
Appearance	Off-white to pale yellow amorphous powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥95.0%
Related Substances	Individual impurity ≤0.5%; Total impurities ≤3.0%
Residue on Ignition	≤0.5%
Water (Karl Fischer)	≤5.0%
Solubility	Soluble in DMSO, methanol, and acetonitrile; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.