Description

Lipstatin is a potent and specific inhibitor of pancreatic lipase, the primary enzyme responsible for dietary fat digestion. This compound matters significantly as a key intermediate in the synthesis of the anti-obesity drug Orlistat (Xenical®/Alli®). Pharmaceutical manufacturers and advanced research institutions require high-purity Lipstatin CAS NO 96829-59-3 for the development and production of therapeutic agents targeting weight management and metabolic disorders.

Application

• Active Pharmaceutical Ingredient (API) Intermediate: Primary use as the critical precursor in the commercial synthesis of Orlistat.
• Pharmaceutical Research & Development: Used in metabolic disease research to study lipase inhibition mechanisms and develop new therapeutics.
• Biochemical Tool Compound: Employed in in vitro assays to selectively inhibit lipase activity for studying fat metabolism pathways.
• Reference Standard: Serves as a high-purity analytical standard for quality control in pharmaceutical manufacturing.

Basic Information

Product Name	Lipstatin
CAS No.	96829-59-3
Molecular Formula	C29H49NO4
Molecular Weight	475.71 g/mol
Synonyms	(2S)-1-[(2S,3S)-3-Hexyl-4-oxo-2-oxetanyl]methyl]dodecyl (2S)-2-formamido-3-methylpentanoate; N-Formyl-L-leucine (3S,4S)-3-hexyl-4-[(2S)-2-[(1S)-1-hydroxypentadecyl]oxiranyl]-2-oxetanone ester; Tetrahydrolipstatin precursor; Orlistat intermediate; Lipase inhibitor 96829-59-3
EINECS	Contact for details

Quality Control

Our Lipstatin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for pharmaceutical intermediate use. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a controlled environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.