Description

20-Methyl-13,14-Didehydro-2,4-Inter-3-Phenylene Prostaglandin I2 is a synthetic prostaglandin I2 (prostacyclin) analog, a potent vasodilator and inhibitor of platelet aggregation. This compound is valued for its high biological activity and stability profile, making it a critical intermediate in advanced pharmaceutical research and development. It is primarily utilized by research institutions and pharmaceutical companies focused on cardiovascular therapeutics, pulmonary arterial hypertension (PAH) treatments, and novel anti-thrombotic agents.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel prostacyclin-based therapeutics.
• Cardiovascular Research: Used in preclinical studies to investigate vasodilation, platelet function, and vascular remodeling.
• Pulmonary Arterial Hypertension (PAH) Drug Development: Serves as a reference compound and precursor for developing next-generation PAH medications.
• Biochemical Research: A tool compound for studying IP receptor (prostacyclin receptor) signaling pathways and endothelial function.
• Reference Standard: Employed as an analytical standard in quality control and method development for related pharmaceutical products.

Basic Information

Product Name	20-Methyl-13,14-Didehydro-2,4-Inter-3-Phenylene Prostaglandin I2
CAS No.	96744-62-6
Molecular Formula	C24H30O5
Molecular Weight	398.50 g/mol
Synonyms	20-Methyl-13,14-didehydro-2,4-inter-m-phenylene PGI2; 20-Methyl-δ13,14-2,4-inter-m-phenylene Prostacyclin I2; 20-Methylcarbacyclin derivative; Prostacyclin I2 analog; Iloprost intermediate; Treprostinil-related compound; 6,9α-Epoxy-11α,15α-dihydroxy-20-methyl-13,14-didehydro-2,4-inter-m-phenylene-5-thiaprosta-6,13-dien-1-oic acid (theoretical); CAS 96744-62-6
EINECS	Contact for details

Quality Control

Our 20-Methyl-13,14-Didehydro-2,4-Inter-3-Phenylene Prostaglandin I2 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade standards. Specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at -20°C or below to ensure long-term stability. This product is hygroscopic (moisture-sensitive) and easily oxidized; therefore, containers should be allowed to reach room temperature in a desiccator before opening to minimize exposure to moisture and air.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.