Description

6-Fluoromevalonate-5-Pyrophosphate is a high-purity, fluorinated analog of mevalonate pyrophosphate, a critical intermediate in the isoprenoid biosynthesis pathway. This compound is specifically engineered for research and development applications where modulation of this metabolic pathway is required. It is primarily utilized by pharmaceutical researchers, biochemists, and process development scientists in the life sciences sector.

Application

• Enzymology Research: As a substrate analog for studying the mechanism and inhibition of key enzymes in the mevalonate pathway, such as mevalonate kinase and phosphomevalonate kinase.
• Metabolic Pathway Analysis: Used in tracer studies and biochemical assays to investigate the biosynthesis of isoprenoids, sterols, and other downstream metabolites.
• Drug Discovery & Development: Serves as a valuable tool compound for screening and developing novel therapeutics targeting cholesterol synthesis, bone disorders, or certain cancers linked to isoprenoid signaling.
• Biochemical Probe: Acts as a specific probe to dissect the role of the mevalonate pathway in cellular processes, including protein prenylation and cell growth regulation.
• Academic Research: Employed in university and institutional labs for fundamental research in biochemistry, molecular biology, and metabolic engineering.
• Process Chemistry: Potential use as a sophisticated building block or reference standard in the synthesis of more complex fluorinated bioactive molecules.

Basic Information

Product Name	6-Fluoromevalonate-5-Pyrophosphate
CAS No.	96643-92-4
Molecular Formula	C6H11FO10P23- (Commonly supplied as a salt, e.g., ammonium or trisodium)
Molecular Weight	324.09 g/mol (Free acid form)
Synonyms	6-Fluoromevalonic Acid 5-Diphosphate; 6-Fluoro-MVA-5-PP; (R)-6-Fluoromevalonate-5-pyrophosphate; 6-Fluoro-3,5-dihydroxy-3-methylpentanoic acid 5-(dihydrogen phosphate) ester; FMVAPP; 6-Fluoromevalonate diphosphate; 6-F-Mevalonate-5-PP
EINECS	Contact for details

Quality Control

Our 6-Fluoromevalonate-5-Pyrophosphate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the exacting standards required for research applications. A comprehensive Certificate of Analysis (COA) detailing purity (typically by HPLC), identity confirmation (by NMR/IR), and impurity profile is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated under an inert atmosphere. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Identification (IR)	Conforms to reference
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, buffer solutions

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.