Description

2-Methyl-4-Hydroxytamoxifen is a high-purity, non-steroidal selective estrogen receptor modulator (SERM) derivative, primarily utilized as a critical reference standard and advanced pharmaceutical intermediate. Its value lies in enabling precise analytical method development, quality control, and research into estrogen receptor-related pathways. This compound is essential for pharmaceutical R&D laboratories, analytical testing facilities, and manufacturers focused on oncology and endocrine disorder therapeutics.

Application

• Pharmaceutical Reference Standard: Serves as a certified primary standard for the quantitative and qualitative analysis of tamoxifen derivatives in drug substances and finished products.
• Active Pharmaceutical Ingredient (API) Intermediate: A key synthetic precursor in the production of novel SERM-based therapeutic agents.
• Biochemical Research: Used in in vitro and in vivo studies to investigate estrogen receptor modulation, signal transduction, and mechanisms of action in cancer biology.
• Metabolite Studies: Employed as an analytical standard for the identification and quantification of tamoxifen metabolites in pharmacokinetic and bioequivalence studies.
• Quality Control & Assurance: Critical for HPLC, LC-MS, and other chromatographic method validation within QC laboratories of pharmaceutical manufacturers.

Basic Information

Product Name	2-Methyl-4-Hydroxytamoxifen
CAS No.	96474-35-0
Molecular Formula	C26H29NO2
Molecular Weight	387.52 g/mol
Synonyms	4-Hydroxy-2-methyltamoxifen; (Z)-2-[4-[(1E)-1,2-Diphenyl-1-buten-1-yl]phenoxy]-N,N-dimethylethanamine; 2-Methyl-4-hydroxy-tamoxifen; Metabolite E; trans-2-Methyl-4-hydroxytamoxifen; Afimoxifene (related isomer); Z-2-Methyl-4-hydroxytamoxifen
EINECS	Contact for details

Quality Control

Our 2-Methyl-4-Hydroxytamoxifen is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, spectroscopic identification (IR, NMR), and residual solvent analysis, to ensure it meets the stringent requirements for research and pharmaceutical development. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.