Description

Interleukin-1Beta-Converting Enzyme Inhibitor CAS NO 96282-35-8 is a potent and selective small molecule inhibitor of the cysteine protease caspase-1, which is responsible for the proteolytic activation of the pro-inflammatory cytokine interleukin-1β (IL-1β). This compound is a critical research tool for studying the role of IL-1β in inflammatory and autoimmune disease pathways. It is primarily utilized by pharmaceutical R&D departments, academic research institutions, and biotechnology companies focused on immunology, inflammasome research, and novel therapeutic development.

Application

• Biomedical Research: A key pharmacological tool for elucidating the mechanisms of inflammasome activation and IL-1β signaling in cellular and animal models of disease.
• Drug Discovery & Development: Used as a reference standard and lead compound in screening campaigns and preclinical studies targeting caspase-1 for conditions like rheumatoid arthritis, gout, and cryopyrin-associated periodic syndromes (CAPS).
• Inflammation & Immunology Studies: Enables the specific inhibition of IL-1β production to dissect its contribution to septic shock, atherosclerosis, and other chronic inflammatory states.
• Biochemical Assay Development: Serves as a positive control in high-throughput screening (HTS) assays designed to identify novel caspase-1 inhibitors.
• Academic Research: Supports fundamental research in cell biology, apoptosis, and pyroptosis (a form of inflammatory cell death).

Basic Information

Product Name	Interleukin-1Beta-Converting Enzyme Inhibitor
CAS No.	96282-35-8
Molecular Formula	C20H28N4O7
Molecular Weight	436.46 g/mol
Synonyms	Ac-Tyr-Val-Ala-Asp-CHO; Ac-YVAD-CHO; Caspase-1 Inhibitor I; ICE Inhibitor I; Acetyl-Tyr-Val-Ala-Asp-al; Ac-YVAD-aldehyde; Interleukin-1β Converting Enzyme Inhibitor I; Z-YVAD-FMK (related fluoromethyl ketone analog)
EINECS	Contact for details

Quality Control

Our Interleukin-1Beta-Converting Enzyme Inhibitor is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via mass spectrometry (MS) and nuclear magnetic resonance (NMR). We provide comprehensive Certificates of Analysis (COA) with detailed chromatograms and spectral data to ensure reproducibility and reliability for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular weight
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.