Description

Loxistatin is a potent and selective inhibitor of the proteasome, specifically targeting the chymotrypsin-like activity. This compound is a critical research tool for studying protein degradation pathways, cellular apoptosis, and the ubiquitin-proteasome system. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on oncology, neurodegenerative diseases, and inflammation.

Application

• Biochemical Research: A key reagent for investigating the mechanisms of the 20S and 26S proteasome complexes in vitro and in cell-based assays.
• Drug Discovery & Development: Used as a reference standard and pharmacological tool in screening programs for novel proteasome inhibitors targeting cancer and other diseases.
• Cell Biology Studies: Employed to induce apoptosis and study the effects of proteasomal inhibition on cell cycle regulation, NF-κB signaling, and protein homeostasis.
• Neuroscience Research: Applied in models of neurodegenerative disorders to understand the role of protein aggregation and clearance.
• Inflammation & Immunology: Used to probe the involvement of the proteasome in immune cell function and inflammatory cytokine production.
• Standards & Controls: Serves as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	Loxistatin
CAS No.	96244-68-7
Molecular Formula	C20H30N2O4
Molecular Weight	362.47 g/mol
Synonyms	N-Acetyl-L-leucyl-L-leucyl-L-norleucinal; ALLN; Calpain Inhibitor I; MG-101; Ac-LLN-CHO; Proteasome Inhibitor I; N-Acetyl-Leu-Leu-Nle-CHO
EINECS	Contact for details

Quality Control

Our Loxistatin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. Due to its hygroscopic nature, the product should be handled under anhydrous conditions and allowed to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.