Description

Brequinar CAS NO 96187-53-0 is a potent and selective inhibitor of dihydroorotate dehydrogenase (DHODH), a key enzyme in the de novo pyrimidine biosynthesis pathway. This targeted mechanism of action makes it a critical research tool and a compound of significant interest for therapeutic development. It is primarily utilized by pharmaceutical researchers and life science companies engaged in immunology, oncology, and virology. Its role in modulating lymphocyte proliferation has established it as a valuable reference standard in both academic and industrial R&D settings.

Application

• Immunosuppressive Research: Investigation of mechanisms for autoimmune disease treatment and organ transplant rejection.
• Oncology Research: Study of antiproliferative effects on cancer cells, particularly hematological malignancies.
• Antiviral Research: Exploration of broad-spectrum antiviral activity against RNA and DNA viruses.
• Biochemical Assay Development: Used as a standard inhibitor in DHODH enzyme activity assays.
• Pharmacology & Toxicology Studies: Serves as a reference compound in pharmacokinetic and metabolic studies.
• Cell Culture & In Vitro Models: Applied in studies of lymphocyte activation and proliferation.

Basic Information

Product Name	Brequinar
CAS No.	96187-53-0
Molecular Formula	C23H19F3N2O2
Molecular Weight	412.41 g/mol
Synonyms	Brequinar; Brequinar Sodium; DuP 785; NSC 368390; 6-Fluoro-2-(2'-fluoro-1,1'-biphenyl-4-yl)-3-methyl-4-quinolinecarboxylic acid; DUP-785; 6-Fluoro-2-(2-fluoro[1,1'-biphenyl]-4-yl)-3-methyl-4-quinolinecarboxylic Acid
EINECS	Contact for details

Quality Control

Our Brequinar is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) documenting identity, purity, and impurities is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Unknown Impurity	≤0.5%
Total Impurities	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.