Description

(+)-Thiorphan CAS NO 95909-00-5 is a potent and selective inhibitor of the enzyme neprilysin (NEP), also known as enkephalinase. This high-purity chiral compound is a critical intermediate and research tool in the development of cardiovascular and analgesic pharmaceuticals. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors focused on drug discovery, metabolic studies, and the synthesis of advanced therapeutic agents.

Application

• Pharmaceutical Intermediate: Key chiral building block in the synthesis of advanced drug candidates targeting cardiovascular and central nervous system (CNS) disorders.
• Neprilysin (NEP) Research: A standard and selective inhibitor used in biochemical assays and enzymatic studies to investigate the role of NEP in peptide hormone metabolism.
• Drug Discovery & Development: Utilized in preclinical research for evaluating the therapeutic potential of NEP inhibition in conditions like hypertension, heart failure, and pain management.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis (HPLC, LC-MS).
• Biochemical Tool Compound: Employed in cell-based and in-vivo studies to modulate enkephalin levels and study associated physiological pathways.

Basic Information

Product Name	(+)-Thiorphan
CAS No.	95909-00-5
Molecular Formula	C13H18NO4S2
Molecular Weight	316.41 g/mol
Synonyms	(3R)-N-[(2R)-2-Mercapto-1-oxo-3-phenylpropyl]glycine; (R)-N-((R)-1-Oxo-2-mercapto-3-phenylpropyl)glycine; DL-Thiorphan; Racecadotril impurity; Enkephalinase inhibitor; Neprilysin inhibitor; SQ 28,603; NSC 32623
EINECS	Contact for details

Quality Control

Our (+)-Thiorphan is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the exacting standards required for pharmaceutical research and development. A detailed Certificate of Analysis (COA) with full chromatographic data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. The product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.