Description

Fasciculin I is a highly specific, potent polypeptide neurotoxin isolated from the venom of the green mamba snake (*Dendroaspis angusticeps*). It serves as a powerful and selective inhibitor of acetylcholinesterase (AChE), making it an invaluable tool compound for neurological and pharmacological research. This product is essential for researchers and institutions focused on studying cholinergic systems, enzyme kinetics, and the development of novel therapeutic agents.

Application

• Neurological Research: As a selective inhibitor, it is used to study the structure and function of acetylcholinesterase in the central and peripheral nervous systems.
• Pharmacology & Drug Discovery: Employed in high-throughput screening assays to identify and evaluate new AChE inhibitors for conditions like Alzheimer's disease and myasthenia gravis.
• Biochemical Studies: Used to probe enzyme active sites and investigate catalytic mechanisms of cholinesterases.
• Toxicology Research: Serves as a reference toxin for studying the effects of neurotoxic agents and developing corresponding antidotes.
• Diagnostic Development: Can be utilized in the development of sensitive diagnostic tests for organophosphate and carbamate poisoning.

Basic Information

Product Name	Fasciculin I
CAS No.	95828-61-8
Molecular Formula	C184H282N56O53S7
Molecular Weight	Approx. 4370 g/mol
Synonyms	Fasciculin 1; Fasciculin-1; Toxin F7; Dendrotoxin F7; Acetylcholinesterase Inhibitor Fasciculin I; FAS-I; *Dendroaspis angusticeps* Toxin F7
EINECS	Contact for details

Quality Control

Our Fasciculin I is produced and handled under stringent conditions to ensure the highest standards of purity and biological activity for research applications. Each batch is subjected to comprehensive analytical testing, including HPLC for purity assessment and mass spectrometry for identity confirmation. A detailed Certificate of Analysis (COA) documenting purity, potency, and endotoxin levels is provided with every shipment to guarantee traceability and consistency for your critical research.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized powder at -20°C or below. Reconstituted solutions should be aliquoted and stored at -70°C to -80°C to prevent repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure containers are sealed under anhydrous conditions.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Biological Activity (AChE Inhibition)	≥ 98% of stated activity
Endotoxin Level	< 1.0 EU/µg
Solubility	Soluble in water or buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.