Description

Cicaprost CAS NO 95722-07-9 is a synthetic, stable prostacyclin (PGI2) analog with potent vasodilatory and antiplatelet aggregation properties. Its primary value lies in its enhanced chemical stability compared to natural prostacyclin, making it a critical intermediate and reference standard for pharmaceutical research and development. This compound is essential for researchers and manufacturers in the cardiovascular and pulmonary therapeutic sectors, particularly for investigating treatments for hypertension, pulmonary arterial hypertension (PAH), and thrombotic disorders.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of advanced cardiovascular and pulmonary therapeutics.
• Reference Standard: Used in analytical laboratories for method development, validation, and quality control (QC) of drug substances and finished products.
• Biochemical Research: A vital tool for studying prostacyclin receptor (IP receptor) signaling pathways, platelet function, and vascular smooth muscle relaxation in vitro.
• Preclinical Development: Employed in animal models to evaluate the efficacy and pharmacokinetics of novel prostacyclin-based therapies.
• API Development: Investigated as an active pharmaceutical ingredient (API) candidate for drugs targeting circulatory disorders.

Basic Information

Product Name	Cicaprost
CAS No.	95722-07-9
Molecular Formula	C₂₃H₃₂O₅
Molecular Weight	388.50 g/mol
Synonyms	Cicaprost; ZK 96480; 5-[(1R,2R,3aS,9aS)-2-[(2E)-3,3-Difluoro-4-phenoxybut-2-en-1-yl]-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-1-yl]pentanoic acid; 9a,11a-Methano-11aH-cyclopenta[b]phenanthrene-9-pentanoic acid derivative; Prostacyclin analogue ZK 96480; Iloprost analogue
EINECS	Contact for details

Quality Control

Our Cicaprost is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and residual solvent analysis to ensure it meets high-grade standards suitable for research and development. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed container to reach room temperature before opening to minimize moisture condensation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.