Description

Hymenialdisine CAS NO 95569-43-0 is a potent, naturally occurring alkaloid compound originally isolated from marine sponges, recognized for its unique structural framework and significant biological activity. This compound serves as a critical research tool and a promising lead molecule due to its potent and selective inhibition of key protein kinases, including cyclin-dependent kinases (CDKs) and glycogen synthase kinase-3β (GSK-3β). It is primarily sought by researchers and developers in the pharmaceutical, biotechnology, and life sciences sectors for applications in drug discovery, signal transduction pathway analysis, and the development of novel therapeutic agents targeting cancer, neurodegenerative diseases, and inflammation.

Application

• Pharmaceutical Research & Drug Discovery: As a potent and selective kinase inhibitor for validating novel drug targets and screening compound libraries.
• Oncology Studies: Investigation of cell cycle regulation, apoptosis, and tumor growth inhibition mechanisms due to its activity against CDKs.
• Neurodegenerative Disease Research: Exploration of therapeutic potential for Alzheimer's disease and other tauopathies through GSK-3β inhibition.
• Biochemical Pathway Analysis: A key reagent for studying intracellular signaling cascades involving kinase-mediated phosphorylation events.
• Anti-inflammatory Agent Development: Research into its effects on inflammatory mediators and pathways for potential therapeutic application.
• Chemical Biology & Proteomics: Used as a molecular probe to study kinase function and identify interacting proteins within complex biological systems.
• Academic & Institutional Research: Fundamental studies in marine natural product chemistry, organic synthesis, and medicinal chemistry.

Basic Information

Product Name	Hymenialdisine
CAS No.	95569-43-0
Molecular Formula	C₁₁H₉BrN₄O₂
Molecular Weight	309.12 g/mol
Synonyms	Hymenialdisine; 2-Bromo-9H-purine-6,9-dione, 1,4,5,6,7,8-hexahydro-1,8-dihydroxy-4-(hydroxymethyl)-; 2-Bromohymenialdisine; 1,8-Dihydroxy-4-(hydroxymethyl)-2-bromo-1,4,5,6,7,8-hexahydro-9H-purine-6,9-dione; Marine Alkaloid Hymenialdisine; GSK-3β Inhibitor IV; CDK Inhibitor (Hymenialdisine)
EINECS	Contact for details

Quality Control

Our Hymenialdisine is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high purity, suitable for advanced research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity determination, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. A detailed Certificate of Analysis (COA) documenting all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.