Description

Benzenesulfonyl Fluoride, 3,4-Dimethoxy- is a specialized organosulfur and organofluorine compound that serves as a key chemical intermediate and building block. Its unique structure, featuring both a sulfonyl fluoride group and dimethoxy substituents, makes it a valuable reagent for introducing the sulfonyl fluoride moiety into target molecules, a functional group of high interest in modern synthetic chemistry. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for applications such as medicinal chemistry, chemical biology, and the synthesis of functional polymers.

Application

• Pharmaceutical Intermediate: Used in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly in the development of protease inhibitors and other biologically active molecules.
• Chemical Biology Probe: Acts as a reactive handle in activity-based protein profiling (ABPP) and the development of covalent inhibitors due to the electrophilic nature of the sulfonyl fluoride group.
• Agrochemical Synthesis: Serves as a building block for creating novel herbicides, fungicides, and insecticides with enhanced properties.
• Polymer & Materials Science: Employed in the synthesis of specialty polymers, coatings, and advanced materials where the sulfonyl fluoride group can be used for further functionalization or cross-linking.
• Sulfonylation Reagent: Used in organic synthesis to introduce the 3,4-dimethoxybenzenesulfonyl group into various nucleophiles, creating sulfonamides, sulfonate esters, and other derivatives.
• Cross-Coupling Reactions: Can serve as a substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) to create complex biaryl systems for material or pharmaceutical applications.

Basic Information

Item	Detail
Product Name	Benzenesulfonyl Fluoride, 3,4-Dimethoxy-
CAS No.	95546-50-2
Molecular Formula	C8H9FO4S
Molecular Weight	220.22 g/mol
Synonyms	3,4-Dimethoxybenzenesulfonyl Fluoride; 1,2-Dimethoxy-4-(fluorosulfonyl)benzene; 4-Fluorosulfonyl-1,2-dimethoxybenzene; Veratrole-4-sulfonyl Fluoride; 3,4-Dimethoxybenzene-1-sulfonyl Fluoride
EINECS	Contact for details

Quality Control

Our Benzenesulfonyl Fluoride, 3,4-Dimethoxy- is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high chemical purity and identity. Certificates of Analysis (COA) detailing purity, impurity profile, and physical characteristics are provided with every shipment. We support cGMP and ISO 9001 standards for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.