Description

n-(4-Trifluoromethylbenzyl)Cinchoninum Bromide is a specialized organobromine salt derived from the cinchona alkaloid structure, valued for its role as a chiral phase-transfer catalyst and a versatile synthetic intermediate. Its significance lies in enabling highly enantioselective transformations, which are critical for producing optically pure compounds in advanced pharmaceutical synthesis. This product is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries who require high-purity chiral auxiliaries and catalysts.

Application

• As a chiral phase-transfer catalyst (PTC) for asymmetric alkylation and other carbon-carbon bond-forming reactions.
• Key intermediate in the synthesis of pharmaceutically active compounds, particularly those targeting central nervous system (CNS) disorders.
• Use in asymmetric synthesis for the production of enantiomerically pure amino acids and their derivatives.
• Catalyst for stereoselective fluorination reactions, leveraging the trifluoromethylbenzyl moiety.
• Research and development of novel chiral ionic liquids and organocatalysts.
• Building block for ligand design in transition metal catalysis.
• Reference standard in analytical method development for chiral separation techniques (e.g., HPLC, SFC).

Basic Information

Product Name	n-(4-Trifluoromethylbenzyl)Cinchoninum Bromide
CAS No.	95088-20-3
Molecular Formula	C₂₇H₂₈BrF₃N₂O
Molecular Weight	533.43 g/mol
Synonyms	Cinchoninium, 1-(4-(trifluoromethyl)benzyl)-, bromide (1:1); 1-[(4-Trifluoromethylphenyl)methyl]cinchoninium Bromide; N-(4-Trifluorobenzyl)cinchoninium Bromide; Cinchona Alkaloid-Derived Phase Transfer Catalyst; (8α,9R)-1-[(4-Trifluoromethylphenyl)methyl]cinchonan-9-ium Bromide; PTC Catalyst 95088-20-3; Cinchoninium Bromide Trifluoromethylbenzyl Derivative
EINECS	Contact for details

Quality Control

Our n-(4-Trifluoromethylbenzyl)Cinchoninum Bromide is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and KF titration for moisture content. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.