Description

Butanedioic Acid-1,2-13C2 is a stable isotope-labeled analog of succinic acid, where two carbon atoms at the 1 and 2 positions are enriched with the 13C isotope. This high-purity labeled compound is essential for advanced analytical research, providing a critical internal standard for precise quantification and metabolic pathway tracing. It is primarily utilized by researchers and manufacturers in pharmaceutical development, clinical diagnostics, and metabolic studies who require uncompromised accuracy and isotopic purity for mass spectrometry and NMR applications.

Application

• Internal Standard for Mass Spectrometry (MS): Used for the accurate quantification of endogenous succinic acid in complex biological matrices like plasma, urine, and tissue samples.
• Metabolic Flux Analysis (MFA): A crucial tracer for studying the Krebs cycle and other metabolic pathways in cell cultures, microorganisms, and in vivo models.
• Pharmaceutical Research & Development: Employed in drug metabolism and pharmacokinetics (DMPK) studies to track the fate of drug molecules and their metabolites.
• Clinical Diagnostics: Serves as a reference standard in assays for diagnosing inborn errors of metabolism, such as disorders of mitochondrial function.
• NMR Spectroscopy: Provides a non-radioactive, stable isotopic label for structural elucidation and dynamic studies of biochemical processes.
• Biochemical Research: Used in enzymology studies to investigate the mechanism of action of succinate dehydrogenase and related enzymes.

Basic Information

Product Name	Butanedioic Acid-1,2-13C2
CAS No.	94641-55-1
Molecular Formula	C213C2H6O4
Molecular Weight	120.07 g/mol (for 13C2 labeled form)
Synonyms	Succinic Acid-1,2-13C2; [1,2-13C2]Succinic Acid; 1,2-13C2-Butanedioic Acid; 13C2-Labeled Succinic Acid; Ethylenedicarboxylic Acid-1,2-13C2; Amber Acid-1,2-13C2; Butanedioic-1,2-13C2 Acid
EINECS	Contact for details

Quality Control

Our Butanedioic Acid-1,2-13C2 is manufactured under strict quality systems to ensure the highest isotopic and chemical purity required for sensitive analytical applications. Each batch is characterized by advanced techniques including NMR and LC-MS to confirm isotopic enrichment and chemical identity. A comprehensive Certificate of Analysis (COA) is provided, detailing specifications for isotopic purity, chemical purity, and absence of critical impurities.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. The product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Isotopic Purity (13C)	≥ 99 atom % 13C
Chemical Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (Position 1,2)	≥ 99%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.