Description

19-Allylaminoherbimycin A is a potent ansamycin antibiotic derivative and a well-characterized inhibitor of Hsp90 (Heat Shock Protein 90). This compound matters as a critical research tool in molecular biology and oncology for studying protein folding, client protein degradation, and signal transduction pathways. It is primarily needed by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on cancer therapeutics and neurodegenerative disease research.

Application

• Biochemical Research: Used as a specific Hsp90 inhibitor to study chaperone function, protein homeostasis, and cellular stress responses.
• Oncology Research: Investigated for its role in destabilizing oncogenic client proteins (e.g., HER2, BCR-ABL, mutant p53) leading to apoptosis in cancer cell lines.
• Signal Transduction Studies: Employed to probe the Hsp90-dependent stabilization of kinases and transcription factors involved in cell proliferation and survival pathways.
• Neurodegenerative Disease Models: Utilized in research exploring protein aggregation diseases, such as Alzheimer's and Parkinson's, due to its effects on protein misfolding.
• Antifungal Research: Serves as a reference compound in studies targeting Hsp90 in fungal pathogens, exploring new antifungal strategies.
• Veterinary Research: Applied in preclinical studies for animal cancers, given the conserved nature of the Hsp90 chaperone system across species.

Basic Information

Product Name	19-Allylaminoherbimycin A
CAS No.	94513-96-9
Molecular Formula	C₃₁H₄₃N₃O₈
Molecular Weight	585.70 g/mol
Synonyms	19-Allylamino-17-demethoxygeldanamycin; 19-AAG; NSC 330507; 17-DMAG analogue; Benzoquinone ansamycin 19-allylamino derivative; Antibiotic MA 957; Hsp90 Inhibitor 19-AAG
EINECS	Contact for details

Quality Control

Our 19-Allylaminoherbimycin A is produced and handled under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, potency, and stability data.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. The product is hygroscopic and light-sensitive; allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.