Description

2-Chloro-4-Fluorobenzotrifluoride is a versatile fluorinated aromatic building block of significant importance in advanced organic synthesis. Its unique structure, featuring both chloro and fluoro substituents on a trifluoromethylated benzene ring, makes it a critical intermediate for creating complex molecules with tailored properties. This compound is primarily sought after by R&D and production teams in the pharmaceutical and agrochemical industries, where it serves as a key precursor for active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in molecules requiring a substituted benzotrifluoride moiety for enhanced metabolic stability and lipophilicity.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and insecticides, where the fluorine and chlorine atoms contribute to biological activity and environmental persistence.
• Liquid Crystal Materials: Serves as a building block for fluorinated liquid crystal compounds used in display technologies.
• Functional Polymer Monomer: Incorporated into specialty polymers to impart unique chemical resistance, thermal stability, or specific surface properties.
• Organic Electronic Materials: Investigated as a component in the synthesis of materials for organic light-emitting diodes (OLEDs) and semiconductors.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, or Buchwald-Hartwig amination, enabling rapid diversification of chemical libraries.

Basic Information

Product Name	2-Chloro-4-Fluorobenzotrifluoride
CAS No.	94444-58-3
Molecular Formula	C7H3ClF4
Molecular Weight	198.55 g/mol
Synonyms	1-Chloro-2-fluoro-5-(trifluoromethyl)benzene; 2-Chloro-α,α,α-trifluoro-p-fluorotoluene; 2-Chloro-4-fluorobenzylidene trifluoride; 2-Chloro-4-fluoro-α,α,α-trifluorotoluene; 4-Fluoro-2-chlorobenzotrifluoride; 5-Chloro-2-fluorobenzotrifluoride; Benzene, 1-chloro-2-fluoro-5-(trifluoromethyl)-; p-Fluoro-o-chlorobenzotrifluoride
EINECS	Contact for details

Quality Control

Our 2-Chloro-4-Fluorobenzotrifluoride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases. Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use to prevent evaporation and concentration changes. Recommended storage temperature is 2-25°C.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.1%
Related Substances (GC)	Total impurities ≤ 2.0%
Density (at 20°C)	~1.45 g/mL
Refractive Index (n20D)	~1.435

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.