Description

Pkm2 Inhibitor CAS NO 94164-88-2 is a potent and selective small molecule inhibitor of the pyruvate kinase M2 (PKM2) isozyme, a key regulatory enzyme in the glycolytic pathway. This compound is of significant interest for its role in modulating cellular metabolism, particularly in rapidly proliferating cells. It serves as a critical research tool for scientists in oncology, metabolic disease research, and cell biology, enabling the study of the Warburg effect and tumor metabolism.

Application

• Biochemical Research: Used as a selective tool compound to study PKM2 enzyme kinetics, allosteric regulation, and its role in aerobic glycolysis (the Warburg effect).
• Oncology and Cancer Research: Investigated for its potential to inhibit cancer cell proliferation and tumor growth by targeting the metabolic reprogramming characteristic of many malignancies.
• Metabolic Pathway Analysis: Employed in cell-based assays and in vitro studies to dissect the complex interplay between glycolysis, mitochondrial function, and cell signaling.
• Drug Discovery & Development: Serves as a lead compound or pharmacophore model for the design and optimization of novel therapeutic agents targeting metabolic enzymes.
• Academic & Pharmaceutical R&D: A standard reagent in laboratories focusing on cell metabolism, signal transduction, and the identification of new targets for metabolic diseases.

Basic Information

Product Name	Pkm2 Inhibitor
CAS No.	94164-88-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	PKM2 Inhibitor; Pyruvate Kinase M2 Inhibitor; 7-(4-(Trifluoromethyl)phenyl)-2,3-dihydro-1H-pyrrolo[1,2-a]benzimidazole; Compound 3K; Shikonin (a known natural PKM2 inhibitor, often referenced in context); TLN-232 (Capoxatone); PKM2i.
EINECS	Contact for details

Quality Control

Our Pkm2 Inhibitor is produced under strict quality management protocols to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical characterization, including purity verification and identity confirmation. A Certificate of Analysis (COA) detailing specific test results is provided with every shipment to guarantee it meets the stringent requirements of life science research.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider keeping the product at -20°C under desiccant.

Specification

Item	Specification
Appearance	Yellow to brown solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.