Description

4-(Trifluoromethoxy)Benzenesulfonyl Chloride is a versatile and highly reactive organosulfur compound, serving as a critical sulfonylation reagent in advanced organic synthesis. Its value lies in the unique combination of the sulfonyl chloride functional group and the electron-withdrawing trifluoromethoxy substituent, which enables the efficient introduction of the 4-(trifluoromethoxy)phenylsulfonyl moiety into target molecules. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients, and is also valuable in materials science for creating specialized polymers and ligands.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of sulfonamide-based drug candidates, including protease inhibitors and receptor antagonists.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides that benefit from the enhanced metabolic stability imparted by the trifluoromethoxy group.
• Material Science: Employed in the creation of specialty polymers, dyes, and liquid crystals where the sulfonyl group modifies physical properties.
• Chemical Research: A valuable reagent in academic and industrial R&D for exploring new synthetic methodologies and creating molecular libraries.
• Ligand & Catalyst Development: Serves as a precursor for synthesizing specialized ligands used in catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	4-(Trifluoromethoxy)Benzenesulfonyl Chloride
CAS No.	94108-56-2
Molecular Formula	C7H4ClF3O3S
Molecular Weight	260.62 g/mol
Synonyms	1-(Trifluoromethoxy)-4-(chlorosulfonyl)benzene; p-(Trifluoromethoxy)benzenesulfonyl chloride; 4-(Trifluoromethoxy)phenylsulfonyl chloride; 4-Trifluoromethoxybenzenesulfonyl chloride; Benzenesulfonyl chloride, 4-(trifluoromethoxy)-; α,α,α-Trifluoro-p-anisolesulfonyl chloride
EINECS	Contact for details

Quality Control

Our 4-(Trifluoromethoxy)Benzenesulfonyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis. Keep away from strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.