Description

Bis[(S)-Nicotine] Citrate is a high-purity, enantiomerically defined salt of nicotine and citric acid. This compound is critical for applications requiring a consistent and well-characterized source of the (S)-nicotine enantiomer, which is the naturally occurring and biologically active form. It serves as a key intermediate and reference standard for pharmaceutical research, analytical chemistry, and the development of advanced nicotine delivery systems.

Application

• Pharmaceutical Reference Standard: Used as a certified standard for the quantification and qualification of nicotine in analytical methods (e.g., HPLC, GC).
• Biochemical Research: Employed in studies of nicotinic acetylcholine receptors (nAChRs) and neuropharmacology due to its defined stereochemistry.
• Advanced Nicotine Product Development: Serves as a precise active pharmaceutical ingredient (API) in the formulation of nicotine replacement therapies (NRTs) and other regulated products.
• Chemical Synthesis: Acts as a chiral building block or precursor for the synthesis of more complex nicotine derivatives and analogs.
• Quality Control Laboratories: Essential for method validation, system suitability testing, and ensuring regulatory compliance in manufacturing.

Basic Information

Product Name	Bis[(S)-Nicotine] Citrate
CAS No.	94006-00-5
Molecular Formula	C22H28N4O7
Molecular Weight	460.48 g/mol
Synonyms	(S)-Nicotine Citrate; Nicotine Citrate; 1:2 Nicotine Citrate; Nicotine Hydrogen Citrate; Nicotine Citrate Dihydrate (common form); (-)-Nicotine Citrate; L-Nicotine Citrate; 3-[(2S)-1-Methyl-2-pyrrolidinyl]pyridine citrate (2:1)
EINECS	Contact for details

Quality Control

Every batch of our Bis[(S)-Nicotine] Citrate is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure identity, purity, and consistency, meeting the stringent requirements for research and pharmaceutical applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting key parameters such as assay, enantiomeric purity, and impurity profile.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccant use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0% (anhydrous basis)
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% (S)-isomer
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.