Description

5-Nitroprostaglandin I1 is a chemically modified prostaglandin analog, specifically a nitrated derivative of prostacyclin (PGI1). This compound is of significant interest in advanced biomedical research due to its potential to modulate vascular and inflammatory pathways with altered potency and metabolic stability compared to its parent molecule. It is primarily utilized by pharmaceutical R&D teams and academic researchers focused on cardiovascular pharmacology, inflammation studies, and the development of novel therapeutic agents targeting prostacyclin receptors.

Application

• Pharmaceutical Research & Development: Serves as a key intermediate or reference standard in the synthesis and study of novel cardiovascular and anti-inflammatory drugs.
• Biochemical Research: Used as a pharmacological tool to investigate the role of nitrated eicosanoids in cell signaling, vascular tone, and platelet aggregation.
• Prostacyclin Receptor Studies: Acts as a specific ligand or modulator in assays designed to study IP receptor activation, desensitization, and downstream effects.
• Metabolic Pathway Analysis: Employed in studies exploring the metabolic fate and biological activity of nitro-fatty acids and related signaling molecules.
• Reference Standard: Used in analytical laboratories for method development and validation in HPLC, LC-MS, or other chromatographic techniques for quantifying prostaglandins and their derivatives.

Basic Information

Product Name	5-Nitroprostaglandin I1
CAS No.	93984-39-5
Molecular Formula	C₂₀H₃₁NO₆
Molecular Weight	381.47 g/mol
Synonyms	5-Nitro-PGI1; 5-Nitroprostacyclin I1; 9-Deoxy-9α,11α-epoxy-5-nitro-15S-hydroxyprosta-5Z,13E-dien-1-oic Acid; 5-Nitro-PGI₂; Nitroprostacyclin; 5-Nitro Prostaglandin I1
EINECS	Contact for details

Quality Control

Every batch of 5-Nitroprostaglandin I1 is produced and analyzed under strict quality management protocols to ensure identity, purity, and consistency for research applications. Our standard material is characterized by multiple spectroscopic and chromatographic methods. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation. Allow the sealed container to reach room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.