Description

±-Artemether-D3 is a deuterated analog of the potent antimalarial drug artemether, where specific hydrogen atoms are replaced with deuterium. This isotopic labeling is crucial for advanced pharmaceutical research and development, particularly in drug metabolism and pharmacokinetics (DMPK) studies. It serves as an essential internal standard for the precise quantitative analysis of artemether and its metabolites using sophisticated techniques like LC-MS/MS. This high-purity compound is primarily utilized by research institutions, pharmaceutical R&D laboratories, and analytical service providers focused on antimalarial drug development and bioanalytical method validation.

Application

• Internal Standard for Bioanalysis: Serves as a critical deuterated internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) for the accurate quantification of artemether in biological matrices such as plasma, blood, and tissues.
• Drug Metabolism Studies (DMPK): Used in pharmacokinetic (PK) and pharmacodynamic (PD) research to trace and understand the metabolic pathways, bioavailability, and clearance of artemether.
• Pharmaceutical R&D: Supports the development and quality control of new artemisinin-based combination therapies (ACTs) and generic formulations.
• Clinical Research: Enables precise therapeutic drug monitoring (TDM) and bioequivalence studies in clinical trials for antimalarial medications.
• Forensic and Anti-counterfeiting Analysis: Aids in the authentication of pharmaceutical products and the investigation of drug quality in public health sectors.
• Stable Isotope Labeling: Acts as a reference material in studies utilizing stable isotopes to investigate chemical and biological processes.

Basic Information

Item	Detail
Product Name	±-Artemether-D3
CAS No.	93861-34-8
Molecular Formula	C16H23D3O5
Molecular Weight	~301.40 g/mol
Synonyms	Artemether-d3; Dihydroartemisinin Methyl Ether-d3; (3R,5aS,6R,8aS,9R,10S,12R,12aR)-Decahydro-10-methoxy-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-d3; (+)-Artemether-d3; Arteether-d3 (common name variant); Deuterated Artemether; [2H3]-Artemether; Internal Standard for Artemether
EINECS	Contact for details

Quality Control

Our ±-Artemether-D3 is manufactured under strict quality management systems to ensure the high purity and isotopic enrichment required for analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as chemical purity, isotopic purity (deuteration degree), and identity confirmation via spectroscopic methods. We adhere to relevant industry standards for reference materials. Certificates of Analysis (COA) are available upon request to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). For long-term stability, storage at 2-8°C is recommended. Keep the container sealed in a dry, inert environment to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98 atom % D (D3 species)
Chemical Purity	≥ 95%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.