Description

Ursodeoxycholic Acid-D5 is a deuterium-labeled analog of the primary therapeutic bile acid, ursodeoxycholic acid (UDCA). This stable isotope-labeled compound is essential for advanced analytical and research applications where precise quantification and metabolic pathway tracing are required. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in pharmacokinetic, metabolic, and bioanalytical studies.

Application

• Internal Standard for Quantitative Analysis: Serves as a critical internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) for the accurate quantification of endogenous UDCA and its metabolites in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used as a tracer to investigate the absorption, distribution, metabolism, and excretion (ADME) profiles of ursodeoxycholic acid in preclinical and clinical research.
• Biochemical Pathway Research: Enables detailed study of bile acid synthesis, enterohepatic circulation, and related metabolic disorders.
• Pharmaceutical Reference Standard: Acts as a high-purity certified reference material (CRM) for method development, validation, and quality control in analytical laboratories.
• Stable Isotope Labeling Studies: Facilitates research into the mechanisms of action of UDCA in treating cholestatic liver diseases, such as primary biliary cholangitis (PBC).

Basic Information

Product Name	Ursodeoxycholic Acid-D5
CAS No.	93701-18-9
Molecular Formula	C24H35D5O4
Molecular Weight	397.59 g/mol
Synonyms	UDCA-D5; Ursodiol-D5; 3α,7β-Dihydroxy-5β-cholan-24-oic-2,2,3,4,4-d5 Acid; Deoxycholic Acid-D5 (7β-hydroxy); (3α,5β,7β)-3,7-Dihydroxycholan-24-oic-2,2,3,4,4-d5 Acid; Choleic Acid-D5; Ursodeoxycholic Acid (Deuterated); 7β-Hydroxylithocholic Acid-D5
EINECS	Contact for details

Quality Control

Our Ursodeoxycholic Acid-D5 is manufactured under strict quality systems to ensure high chemical and isotopic purity suitable for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as chemical purity (by HPLC), isotopic enrichment, and identification. We adhere to relevant industry standards for reference materials, and custom synthesis to meet specific pharmacopeial or client specifications is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (Mass Spectrometry)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity (Titration)	Contact for details
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.