Description

1-Fluoro-2-(2,2,2-trifluoroethyl)benzene is a specialized fluorinated aromatic building block of significant interest in advanced organic synthesis. Its value lies in the unique combination of a fluorine substituent and a trifluoroethyl side chain, which can dramatically alter the electronic properties, metabolic stability, and lipophilicity of target molecules. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries seeking to develop novel active ingredients with enhanced performance profiles.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders, anti-inflammatory agents, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine and trifluoroethyl groups contribute to biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated components for electronic display materials and organic light-emitting diodes (OLEDs), improving charge transport and device efficiency.
• Advanced Polymer Chemistry: Incorporated as a monomer or modifier to create specialty polymers with enhanced chemical resistance, thermal stability, and unique surface properties.
• Fluorine-18 Radiochemistry: Potential use as a precursor or model compound in the development of Positron Emission Tomography (PET) imaging tracers.
• Organic Synthesis & Catalysis Research: A valuable reagent for exploring new fluorination methodologies, cross-coupling reactions, and as a ligand in catalyst design.

Basic Information

Product Name	1-Fluoro-2-(2,2,2-trifluoroethyl)benzene
CAS No.	93524-64-2
Molecular Formula	C8H6F4
Molecular Weight	178.13 g/mol
Synonyms	2-(2,2,2-Trifluoroethyl)fluorobenzene; 1-Fluoro-2-(trifluoroethyl)benzene; α,α,α-Trifluoro-o-fluoroethylbenzene; o-Fluoro-α,α,α-trifluoroethylbenzene; Benzene, 1-fluoro-2-(2,2,2-trifluoroethyl)-; 2-Fluoro-α,α,α-trifluoroethylbenzene; (2-Fluorophenyl)(trifluoro)methane
EINECS	Contact for details

Quality Control

Our 1-Fluoro-2-(2,2,2-trifluoroethyl)benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing identity, assay, and impurity profiles to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids, bases, and oxidizing agents. Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use. Recommended storage temperature: 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Individual impurity ≤ 1.0%
Density (at 20°C)	~1.30 g/mL
Refractive Index (n20D)	~1.42

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.