Description

4-Methyl-2-oxopentanoic-1-13C acid sodium salt is a stable-isotope labeled derivative of 4-methyl-2-oxopentanoic acid, where the carbon at the 1-position is the 13C isotope. This compound is a critical reagent in metabolic pathway research and tracer studies, offering high isotopic purity for precise analytical measurements. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and advanced life science sectors for applications in drug metabolism, proteomics, and stable isotope labeling.

Application

• Stable Isotope Labeling in Metabolic Flux Analysis (MFA): Used as a 13C-labeled tracer to study central carbon metabolism in cells, providing insights into pathway activities and regulation.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Serves as an internal standard in mass spectrometry for the accurate quantification of metabolites, enhancing data reliability.
• Proteomics and Biomarker Discovery: Employed in isotope-coded affinity tag (ICAT) or similar techniques for comparative protein expression analysis.
• NMR Spectroscopy: Acts as a 13C-enriched substrate for nuclear magnetic resonance studies to elucidate metabolic structures and dynamics.
• Biochemical Research Reagent: Used in enzymatic assays and studies related to branched-chain amino acid metabolism, particularly leucine catabolism.
• Manufacturing of Labeled Compounds: A key synthetic intermediate for the production of more complex 13C-labeled pharmaceuticals or fine chemicals.

Basic Information

Product Name	4-Methyl-2-oxopentanoic-1-13C acid sodium salt
CAS No.	93523-70-7
Molecular Formula	C6H9NaO3 (with 13C at C-1)
Molecular Weight	Approx. 152.12 g/mol (13C adjusted)
Synonyms	4-Methyl-2-oxopentanoic-1-13C acid sodium salt; Sodium 4-methyl-2-oxopentanoate-1-13C; 2-Ketoisocaproic-1-13C acid sodium salt; α-Ketoisocaproate-1-13C sodium salt; KIC-1-13C sodium salt; 4-Methyl-2-oxovaleric-1-13C acid sodium salt; (13C)Leucine metabolite sodium salt; Sodium 2-oxo-4-methylpentanoate-1-13C
EINECS	Contact for details

Quality Control

Our 4-Methyl-2-oxopentanoic-1-13C acid sodium salt is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical and isotopic purity, meeting the exacting standards required for research and diagnostic applications. Certificates of Analysis (COA) are provided, detailing parameters such as assay (HPLC), isotopic enrichment (NMR/MS), and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Isotopic Enrichment (13C)	≥ 99 atom %
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.