Description

(+/-)-Bay K 8644 CAS NO 93468-89-4 is a well-characterized calcium channel agonist, specifically a 1,4-dihydropyridine derivative, widely used as a potent research tool in pharmacological and physiological studies. Its primary value lies in its ability to modulate L-type voltage-gated calcium channels, making it indispensable for investigating calcium signaling pathways, cardiac function, and smooth muscle contraction. This compound is essential for researchers and developers in the pharmaceutical, biotechnology, and academic sectors focused on cardiovascular research, neurobiology, and drug discovery.

Application

• Cardiovascular Research: Used as a standard tool to study L-type calcium channel function in cardiac myocytes, investigating inotropic effects and arrhythmia mechanisms.
• Neuropharmacology: Employed to probe the role of voltage-gated calcium channels in neurotransmitter release, neuronal excitability, and synaptic plasticity.
• Smooth Muscle Physiology: Applied in studies of vascular and non-vascular smooth muscle contraction, aiding research into hypertension and vasospasm.
• Drug Discovery & Screening: Serves as a reference agonist in high-throughput screening assays to identify novel calcium channel modulators or antagonists.
• Cellular Signaling Pathways: Utilized to elucidate intracellular calcium-dependent processes, including gene expression, enzyme activation, and cell proliferation.
• Academic & Institutional Research: A key reagent for basic science investigations in university and government laboratory settings.

Basic Information

Product Name	(+/-)-Bay K 8644
CAS No.	93468-89-4
Molecular Formula	C22H23N3O6
Molecular Weight	425.44 g/mol
Synonyms	Bay K 8644; Methyl 1,4-dihydro-2,6-dimethyl-3-nitro-4-(2-trifluoromethylphenyl)-pyridine-5-carboxylate; (RS)-Bay K 8644; (±)-Bay K 8644; 3-Nitro-2,6-dimethyl-4-(2-trifluoromethylphenyl)-1,4-dihydropyridine-5-carboxylic acid methyl ester; BAY-K-8644; BAY K8644
EINECS	Contact for details

Quality Control

Our (+/-)-Bay K 8644 is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and reliability for critical research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity verification and spectroscopic identification (NMR, IR, MS). A detailed Certificate of Analysis (COA) providing full specification data is supplied with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. The product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider desiccant use within the primary container.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.