Description

1-(2-Bromoethyl)-3,5-Bis(Trifluoromethyl)Benzene is a high-value, multi-functional organic building block characterized by its reactive bromoethyl side chain and electron-deficient bis(trifluoromethyl)benzene core. This compound is essential for introducing the lipophilic and metabolically stable 3,5-bis(trifluoromethyl)phenyl moiety into target molecules, a key strategy in modern pharmaceutical and agrochemical design. It is primarily sought by R&D chemists and process development scientists in the life sciences and advanced materials sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in candidates targeting central nervous system (CNS) disorders, oncology, and inflammation, where the trifluoromethyl groups enhance bioavailability and binding affinity.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides, where the compound's structural motif contributes to improved pest selectivity and environmental stability.
• Ligand & Catalyst Development: Serves as a precursor for sophisticated phosphine or nitrogen-based ligands in transition metal catalysis, enabling challenging cross-coupling and asymmetric synthesis reactions.
• Material Science Research: Employed in the development of organic semiconductors, liquid crystals, and specialty polymers, where the aromatic fluorinated unit influences electronic properties and material stability.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global pharmaceutical and agrochemical clients.

Basic Information

Product Name	1-(2-Bromoethyl)-3,5-Bis(Trifluoromethyl)Benzene
CAS No.	93427-29-3
Molecular Formula	C10H7BrF6
Molecular Weight	321.06 g/mol
Synonyms	2-Bromo-1-[3,5-bis(trifluoromethyl)phenyl]ethane; 1-(2-Bromoethyl)-3,5-bis(trifluoromethyl)benzene; 2-[3,5-Bis(trifluoromethyl)phenyl]ethyl bromide; 3,5-Bis(trifluoromethyl)phenethyl bromide; α,α,α,α',α',α'-Hexafluoro-3,5-xylylethyl bromide; (3,5-Bis(trifluoromethyl)phenyl)ethyl bromide
EINECS	Contact for details

Quality Control

Our production of 1-(2-Bromoethyl)-3,5-Bis(Trifluoromethyl)Benzene adheres to stringent quality management protocols to ensure batch-to-batch consistency and reliability for critical synthetic applications. Each lot is subjected to comprehensive analytical characterization, including HPLC, GC, NMR, and mass spectrometry, to verify identity, purity, and the absence of critical impurities. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications. We support compliance with cGMP and ISO 9001 standards for pharmaceutical and industrial customers.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The product is light-sensitive (store away from light). Keep the container tightly sealed under an inert atmosphere if prolonged storage is anticipated to minimize potential degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.