Description

4'-(3-Iodo-4-Azidobenzene Sulfonyl)Cymarin is a specialized, multi-functional chemical probe derived from the cardiac glycoside cymarin. This compound matters as a critical research tool for studying and labeling biological targets, particularly in the fields of enzymology and receptor biology, due to its integrated photoaffinity labeling (azido group) and detection (iodo group) capabilities. It is primarily needed by researchers and developers in pharmaceutical R&D, biochemistry, and molecular biology for investigating protein interactions, enzyme mechanisms, and developing targeted therapies.

Application

• Photoaffinity Labeling Probe: Used to covalently tag and study protein targets, enzyme active sites, and receptor binding pockets upon UV light activation.
• Biochemical Research Reagent: Serves as a key intermediate or tool compound in mechanistic studies of cardiac glycoside interactions and sodium-potassium ATPase (Na+/K+-ATPase) inhibition.
• Proteomics and Chemical Biology: Enables the identification and isolation of novel drug targets through cross-linking and subsequent pull-down assays.
• Pharmaceutical Development: Utilized in early-stage drug discovery for validating target engagement and understanding structure-activity relationships (SAR) of cymarin derivatives.
• Radiolabeling Precursor: The iodine atom provides a potential site for radioiodination (e.g., with I-125) to create radioactive tracers for imaging or quantitative binding studies.

Basic Information

Product Name	4'-(3-Iodo-4-Azidobenzene Sulfonyl)Cymarin
CAS No.	93422-88-9
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	4'-(3-Iodo-4-azidobenzenesulfonyl)cymarin; 3'-Iodo-4'-azidobenzenesulfonylcymarin; Cymarin, 4'-(3-iodo-4-azidobenzenesulfonyl)-; Photoaffinity cymarin probe; Iodoazidobenzenesulfonyl cymarin; Azidophenylsulfonyl cymarin derivative; ATPase photoaffinity label
EINECS	Contact for details

Quality Control

Our 4'-(3-Iodo-4-Azidobenzene Sulfonyl)Cymarin is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity verification and spectroscopic methods (NMR, MS) for structural confirmation, to ensure it meets the high standards required for research applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. Due to the presence of a light-sensitive azido group and potential thermal instability, this material must be handled and stored with strict adherence to light-protection measures (e.g., amber vials, foil wrapping) and kept frozen for long-term stability. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in alcohols

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.